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Artículo

Histological characterization of gonadotropin-releasing hormone (GnRH) in the hypothalamus of the South American plains vizcacha (Lagostomus maximus)

Dorfman, Verónica BertaIcon ; Fraunhoffer Navarro, Nicolas AlejandroIcon ; Inserra, Pablo Ignacio FelipeIcon ; Loidl, Cesar FabianIcon ; Vitullo, Alfredo DanielIcon
Fecha de publicación: 08/2011
Editorial: Springer
Revista: Journal of Molecular Histology
ISSN: 1567-2379
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

In contrast to most mammalian species, females of the South American plains vizcacha, Lagostomus maximus, show an extensive suppression of apoptosisdependent follicular atresia, continuous folliculogenesis, and massive polyovulation. These unusual reproductive features pinpoint to an eventual peculiar modulation of the hypothalamo-hypophyseal-gonadal axis through its main regulator, the gonadotropin-releasing hormone (GnRH). We explored the hypothalamic histological landscape and cellular and subcellular localization of GnRH in adult nonpregnant L. maximus females. Comparison to brain atlases from mouse, rat, guinea pig and chinchilla enabled us to histologically define and locate the preoptic area (POA), the ventromedial nucleus, the median eminence (ME), and the arcuate nucleus (Arc) of the hypothalamus in vizcacha's brain. Specific immunolocalization of GnRH was detected in soma of neurons at medial POA (MPA), ventrolateral preoptic nucleus, septohypothalamic nucleus (SHy) and Arc, and in beaded fibers of MPA, SHy, ventromedial hypothalamic nucleus, anterior hypothalamic area and ME. Electron microscopy examination revealed GnRH associated to cytoplasmic vesicles of the ME and POA neurons, organized both in core and non-core vesicles within varicosities, and in neurosecretory vesicles within the myelinated axons of the MPA. Besides the peculiar and unusual features of folliculogenesis and ovulation in the vizcacha, these results show that hypothalamus histology and GnRH immune-detection and localization are comparable to those found in other mammals. This fact leads to the possibility that specific regulatory mechanisms should be in action to maintain continuous folliculogenesis and massive polyovulation. © Springer Science+Business Media B.V. 2011.
Palabras clave: Electron Microscopy , Gnrh , Hypothalamus , Immunohistochemistry , Lagostomus Maximus , Plains Vizcacha
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/67779
DOI: https://dx.doi.org/10.1007/s10735-011-9335-5
URL: https://link.springer.com/article/10.1007/s10735-011-9335-5
Colecciones
Articulos(IBCN)
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Dorfman, Verónica Berta; Fraunhoffer Navarro, Nicolas Alejandro; Inserra, Pablo Ignacio Felipe; Loidl, Cesar Fabian; Vitullo, Alfredo Daniel; Histological characterization of gonadotropin-releasing hormone (GnRH) in the hypothalamus of the South American plains vizcacha (Lagostomus maximus); Springer; Journal of Molecular Histology; 42; 4; 8-2011; 311-321
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