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dc.contributor.author
Pavicic, Walter Hernan
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dc.contributor.author
Joensuu, Emmi I.
dc.contributor.author
Nieminen, Taina
dc.contributor.author
Peltomäki, Päivi
dc.date.available
2019-01-08T21:09:42Z
dc.date.issued
2012-07
dc.identifier.citation
Pavicic, Walter Hernan; Joensuu, Emmi I.; Nieminen, Taina; Peltomäki, Päivi; LINE-1 hypomethylation in familial and sporadic cancer; Springer; Journal of Molecular Medicine (Berlin, Germany); 90; 7; 7-2012; 827-835
dc.identifier.issn
0946-2716
dc.identifier.uri
http://hdl.handle.net/11336/67741
dc.description.abstract
Increased and decreased methylation at specific sequences (hypermethylation and hypomethylation, respectively) is characteristic of tumor DNA compared to normal DNA and promotes carcinogenesis in multiple ways including genomic instability. Long interspersed element (LINE), an abundant class of retrotransposons, provides a surrogate marker for global hypomethylation. We developed methylationspecific multiplex ligation-dependent probe amplification assays to study LINE-1 methylation in cases of colorectal, gastric, and endometrial cancer (N0276), stratified by patient category [sporadic; Lynch syndrome (LS); familial colorectal cancer type X (FCCX)] and microsatellite instability status. Within each patient group, LINE-1 showed lower methylation in tumor DNA relative to paired normal DNA and hypomethylation was statistically significant in most cases. Interestingly, normal colorectal mucosa samples from different patient groups displayed differences in LINE-1 methylation that mirrored differences between the respective tumor tissues, with a decreasing trend for LINE-1 methylation from patients with sporadic colorectal cancer to LS to FCCX. Despite the fact that the degree of LINE-1 methylation is generally tissue specific, normal colorectal mucosa, gastric mucosa, and endometrium from LS patients showed similar levels of LINE-1 methylation. Our results suggest that the degree of LINE-1 methylation may constitute a "field defect" that may predispose normal tissues for cancer development. © The Author(s) 2012.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dna Methylation
dc.subject
Gastrointestinal Cancer
dc.subject
Hereditary Cancer
dc.subject
Line-1
dc.subject
Lynch Syndrome
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
LINE-1 hypomethylation in familial and sporadic cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-02T19:31:29Z
dc.journal.volume
90
dc.journal.number
7
dc.journal.pagination
827-835
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Pavicic, Walter Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Helsinski; Finlandia
dc.description.fil
Fil: Joensuu, Emmi I.. University of Helsinski; Finlandia
dc.description.fil
Fil: Nieminen, Taina. University of Helsinski; Finlandia
dc.description.fil
Fil: Peltomäki, Päivi. University of Helsinski; Finlandia
dc.journal.title
Journal of Molecular Medicine (Berlin, Germany)
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00109-011-0854-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00109-011-0854-z
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