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dc.contributor.author
Ferreyra Solari, Nazarena Eugenia
dc.contributor.author
Galoppo, María Cristina
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Cuarterolo, Miriam
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Goñi, Javier
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Fernández Salazar, Luis
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Arranz, Luis E.
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Garrote, Jose A.
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Cherñavsky, Alejandra Claudia
dc.date.available
2019-01-08T21:07:58Z
dc.date.issued
2010-12
dc.identifier.citation
Ferreyra Solari, Nazarena Eugenia; Galoppo, María Cristina; Cuarterolo, Miriam; Goñi, Javier; Fernández Salazar, Luis; et al.; The simultaneous high expression of Vα24, IFN-γ and FoxP3 characterizes the liver of children with type I autoimmune hepatitis; Academic Press Inc Elsevier Science; Clinical Immunology; 137; 3; 12-2010; 396-405
dc.identifier.issn
1521-6616
dc.identifier.uri
http://hdl.handle.net/11336/67731
dc.description.abstract
The immunopathogenesis of type I autoimmune hepatitis (AIH-I) might involve the deregulation of different cellular processes. Here, we investigated the liver expression of selected cytokines and genes of regulatory cell populations in children both at diagnosis and during biochemical remission following immunosuppressive treatment (AIH-Ir). We found a higher Vα24, IFN-γ, FoxP3, IL-27p28, IL-12p40 and IL-21 expression at diagnosis as well as a positive correlation between IL-21 and transaminase levels. Interestingly, only IFN-γ and FoxP3 were decreased in AIH-Ir. An "AIH-I phenotype" (high Vα24, IFN-γ and FoxP3 expression at diagnosis) was observed in only 5 out of 22 AIH-Ir patients but not in controls. These results indicate a local deregulation of the innate and adaptive immune responses with an increased transcriptional activity of immunoregulatory cells at diagnosis. In addition, IL-21 is highlighted as a mediator of liver injury. AIH-Ir is characterized by a partial reversal of the deregulated response. © 2010 Elsevier Inc.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Regulatory Subpopulations
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Th1/Th17 Cytokines
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Type I Autoimmune Hepatitis
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The simultaneous high expression of Vα24, IFN-γ and FoxP3 characterizes the liver of children with type I autoimmune hepatitis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-07T13:35:44Z
dc.journal.volume
137
dc.journal.number
3
dc.journal.pagination
396-405
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Orlando
dc.description.fil
Fil: Ferreyra Solari, Nazarena Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
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Fil: Galoppo, María Cristina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
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Fil: Cuarterolo, Miriam. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Goñi, Javier. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Fernández Salazar, Luis. Hospital Clínico Universitario de Valladolid; España
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Fil: Arranz, Luis E.. Universidad de Valladolid; España
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Fil: Garrote, Jose A.. Universidad de Valladolid; España. Hospital Clínico Universitario de Valladolid; España
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Fil: Cherñavsky, Alejandra Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.journal.title
Clinical Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.clim.2010.08.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1521661610007096
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