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Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice

Elia, Evelin MarielIcon ; Pustovrh, María CarolinaIcon ; Amalfi, SabrinaIcon ; Devoto, Luigi; Motta, Alicia BeatrizIcon
Fecha de publicación: 06 - 2011
Editorial: Elsevier Science Inc
Revista: Fertility and Sterility
Idioma: Inglés
URI: http://hdl.handle.net/11336/67730
https://www.fertstert.org/article/S0015-0282(11)00256-1/fulltext
https://doi.org/10.1016/j.fertnstert.2011.02.004
Citación: Elia, Evelin Mariel; Pustovrh, María Carolina; Amalfi, Sabrina; Devoto, Luigi; Motta, Alicia Beatriz; Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice; Elsevier Science Inc; Fertility and Sterility; 95; 8; 6-2011; 1-5

Abstract

Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect. © 2011 by American Society for Reproductive Medicine.

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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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