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Artículo

Doublecortin (DCX) immunoreactivity in hippocampus of chronic refractory temporal lobe epilepsy patients with hippocampal sclerosis

D`Alessio, LucianaIcon ; Konopka, Hector; Lopez, Ester MariaIcon ; Seoane, Eduardo; Consalvo, Damian; Oddo, Silvia AndreaIcon ; Kochen, Sara SilviaIcon ; López, Juan JoséIcon
Fecha de publicación: 11/2010
Editorial: Elsevier
Revista: Seizure : The Journal Of The British Epilepsy Association
ISSN: 1059-1311
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Medicina Critica y de Emergencia

Resumen

Introduction: Status epilepticus increases the production of new neurons (hippocampal neurogenesis) and promotes aberrant migration. However chronic experimental models of epilepsy and studies performed in human epilepsy showed controversial results suggesting a reduction in hippocampal neurogenesis in late stages of the disease. Doublecortin (DCX) has been validated to determine alterations in the production of new neurons in the human hippocampus. Objectives: Determine DCX expression in human hippocampal sclerosis (HS) from patients who underwent epilepsy surgery for refractory temporal lobe epilepsy (TLE). Methods: Hippocampal sections of 9 patients with HS and TLE who underwent surgery, were processed using immunoperoxidase for DCX. Archival material from 5 normal post-mortem hippocampus were simultaneously processed. Results: Significantly lower staining intensity was observed in DCX-positive neurons localized in dentate gyrus (DG) and in CA1 of epileptic hippocampus; lower DCX reactive area was observed in pyramidal layers of CA1; and a reduced in the mean number of DCX-positive neurons were determined in DG compared to normal hippocampus (p < 0.05). Conclusions: This study found a decrease in DCX expression in hippocampus of patients with HS and chronic and refractory TLE suggesting alterations in NG and hippocampal synaptogenesis with potential cognitive and emotional repercussion.
Palabras clave: Depression , Doublecortin , Hippocampal Neurogenesis , Hippocampal Sclerosis , Temporal Lobe Epilepsy
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/67672
DOI: http://dx.doi.org/10.1016/j.seizure.2010.09.004
URL: https://www.sciencedirect.com/science/article/pii/S1059131110002050
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Articulos(IBCN)
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Citación
D`Alessio, Luciana; Konopka, Hector; Lopez, Ester Maria; Seoane, Eduardo; Consalvo, Damian; et al.; Doublecortin (DCX) immunoreactivity in hippocampus of chronic refractory temporal lobe epilepsy patients with hippocampal sclerosis; Elsevier; Seizure : The Journal Of The British Epilepsy Association; 19; 9; 11-2010; 567-572
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