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dc.contributor.author Ratti, Silvia Gabriela
dc.contributor.author Vizioli, Nora Matilde
dc.contributor.author Gaglio, Eliana
dc.contributor.author Alvarez Toro, Edgardo Orozimbo
dc.date.available 2019-01-08T19:05:04Z
dc.date.issued 2012-12
dc.identifier.citation Ratti, Silvia Gabriela; Vizioli, Nora Matilde; Gaglio, Eliana; Alvarez Toro, Edgardo Orozimbo; Biological Effects of Trace Elements on Lateralized Exploratory Activity, Defensive Behaviour, and Epigenetic DNA Molecular Changes in Maturing Rats; American Scientific Publishers; American Journal of Neuroprotection and Neuroregeneration; 4; 2; 12-2012; 167-175
dc.identifier.issn 1947-2951
dc.identifier.uri http://hdl.handle.net/11336/67670
dc.description.abstract In a previous study, children of a determined geographical zone, characterized by the abundance of mineral deposits in La Rioja, province of Argentina, were found to have altered phenotypic expression attributed to the HSR gene. This gene has been found to be associated to handedness, brain asymmetry, reading-writing abilities and susceptibility to schizophrenia. A hypothesis was raised considering the epigenetic regulation of the HSR gene and its susceptibility to environmental influences; trace elements abundant in this region could be exogenous factors involved in the altered expression attributed to this gene. Thus, the objective of the present work was to test in a cognitive lateralization and associate behavioural responses rat model, the possible biological effect of ZnTe as representative trace element on some spontaneous and natural behavioural responses simile to HSR expression of humans. ZnTe treatment (0.03 µg/L - 3 µg/L) was applied in drinking water to pregnant mother animals along all gestation, delivery, weaning and preadolescent periods. Results showed that ZnTe treatment produced two opposing effects. On one hand, treated young rats displayed excitatory motor and selective motivated exploration responses in a behavioural automatic activity device, and on the other hand, impairments in motivated and lateralized behavioural display in a lateralized exploratory labyrinth. In other different test measuring defensive behaviour, natural defensive responses were attenuated in ZnTe treated rats. Biochemical determinations of the methylation patterns of DNA in prefrontal cortex and hippocampus, showed that ZnTe treatment modified the ratio of non-methylated- to methylated cytosine, suggesting an epigenetic change on the same line to that observed in children in the previous study of this laboratory. In conclusion, the behavioural rat model used in the present study confirms some of the previous evidence found in humans.
dc.format application/pdf
dc.language.iso eng
dc.publisher American Scientific Publishers
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject DEFENSIVE BEHAVIOUR
dc.subject TRACE ELEMENTS
dc.subject METHYL CYTOSINE
dc.subject EPIGENETIC CHANGES
dc.subject.classification Otras Medicina Básica
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Biological Effects of Trace Elements on Lateralized Exploratory Activity, Defensive Behaviour, and Epigenetic DNA Molecular Changes in Maturing Rats
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2019-01-02T19:41:23Z
dc.journal.volume 4
dc.journal.number 2
dc.journal.pagination 167-175
dc.journal.pais Estados Unidos
dc.description.fil Fil: Ratti, Silvia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil Fil: Vizioli, Nora Matilde. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica; Argentina
dc.description.fil Fil: Gaglio, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
dc.description.fil Fil: Alvarez Toro, Edgardo Orozimbo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title American Journal of Neuroprotection and Neuroregeneration
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1166/ajnn.2012.1047
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.ingentaconnect.com/content/asp/ajnn/2012/00000004/00000002/art00009
dc.conicet.fuente individual


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  • Articulos(IMBECU) [269]
    Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
  • Articulos(IQUIFIB) [329]
    Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)