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dc.contributor.author
Caputo, Mariela
dc.contributor.author
Rivolta, Carina Marcela
dc.contributor.author
Mories, Teresa
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Corrales, Juan J.
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Galindo, Purificación
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González Sarmiento, Rogelio
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Targovnik, Hector Manuel
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Miralles-García, José M.
dc.date.available
2019-01-08T18:07:51Z
dc.date.issued
2010-06
dc.identifier.citation
Caputo, Mariela; Rivolta, Carina Marcela; Mories, Teresa; Corrales, Juan J.; Galindo, Purificación; et al.; Analysis of thyroglobulin gene polymorphisms in patients with autoimmune thyroiditis; Springer; Endocrine; 37; 3; 6-2010; 389-395
dc.identifier.issn
1355-008X
dc.identifier.uri
http://hdl.handle.net/11336/67665
dc.description.abstract
The autoimmune thyroid disease is a complex disorder caused by a combination of genetic susceptibility and environmental factors, which are believed to initiate the autoimmune response to thyroid antigens. Identification of the susceptibility genes has found that unique and diverse genetic factors are in association with Graves' disease and autoimmune thyroiditis. The thyroglobulin gene is an identified thyroid-specific gene associated to autoimmune thyroid disease and, principally, with autoimmune thyroiditis. The aim of this work was to test for evidence of allelic association between autoimmune thyroiditis and thyroglobulin polymorphism markers. We studied six polymorphisms distributed throughout all the thyroglobulin gene: four microsatellites (Tgms1, Tgms2, TGrI29 and TGrI30), one insertion/deletion (Indel) polymorphism (IndelTG-IVS18) and one exonic single nucleotide polymorphism (SNP) (c.7589G>A) in 122 patients with autoimmune thyroiditis compared with 100 non-related normal subjects. No differences in allele and genotype distribution were observed between autoimmune thyroiditis cases and controls for Tgms1, Tgms2, TGrI30, IndelTG-IVS18 and c.7589G>A. However, when we analyzed the patients with the TGrI29 microsatellite we found a significant association between the 199-bp allele and AT (33.7% vs. 24.5% in control group) (P = 0.0372). In addition, a higher prevalence of the 201-bp allele has been observed in control subjects (47.5% vs. 38.1% in patients group), although not statistically significant (P = 0.0536). Our work shows the association between the thyroglobulin gene and autoimmune thyroiditis and reinforce that thyroglobulin is a thyroid-specific susceptibility gene for this disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Autoimmune Thyroid Disease
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Autoimmune Thyroiditis
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Genotype Analysis
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Polymorphism
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Thyroglobulin Gene
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Genética Humana
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Analysis of thyroglobulin gene polymorphisms in patients with autoimmune thyroiditis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-07T13:56:15Z
dc.identifier.eissn
1559-0100
dc.journal.volume
37
dc.journal.number
3
dc.journal.pagination
389-395
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Caputo, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina
dc.description.fil
Fil: Rivolta, Carina Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Universidad de Salamanca; España
dc.description.fil
Fil: Mories, Teresa. Universidad de Salamanca; España
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Fil: Corrales, Juan J.. Universidad de Salamanca; España
dc.description.fil
Fil: Galindo, Purificación. Universidad de Salamanca; España
dc.description.fil
Fil: González Sarmiento, Rogelio. Universidad de Salamanca; España
dc.description.fil
Fil: Targovnik, Hector Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Universidad de Salamanca; España
dc.description.fil
Fil: Miralles-García, José M.. Universidad de Salamanca; España
dc.journal.title
Endocrine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12020-010-9317-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s12020-010-9317-5
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