Artículo
Antiproliferative activity of Larrea divaricata Cav. on Lymphoma cell line: Participation of hydrogen peroxide in its action proliferation
Davicino, Roberto Carlos
; Manuele, Maria Gabriela
; Turner, Sebastian Ariel; Ferraro, Graciela Ester
; Anesini, Claudia Alejandra
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
09/2010
Editorial:
Taylor
Revista:
Cancer Investigation
ISSN:
0735-7907
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Larrea divaricata is a plant used in Argentina. The aim was to analyze the participation of H2O2 in the antiproliferative effect of L divaricata on BW5147 cells. Different studies were performed: proliferation, viability, nitrite production, apoptosis, oxygen reducing activity, NF-κ B translocation, H2O2 production, H2O 2 scavenging activity, and effect on exogenous superoxide dismutase. The extract decreased proliferation and induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+-SOD, increasing H 2O2, which was implicated in the antiproliferative mechanism by the increase of Nitric oxide (NO). New drugs, which can increase H2O2, could be a therapeutic strategy for the treatment of cancer.
Palabras clave:
Hydrogen Peroxide
,
Lymphocytes
,
Proliferation
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Davicino, Roberto Carlos; Manuele, Maria Gabriela; Turner, Sebastian Ariel; Ferraro, Graciela Ester; Anesini, Claudia Alejandra; Antiproliferative activity of Larrea divaricata Cav. on Lymphoma cell line: Participation of hydrogen peroxide in its action proliferation; Taylor ; Cancer Investigation; 28; 1; 9-2010; 13-22
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