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Artículo

Coronary intimal thickening in newborn babies and ≤i-Year-old infants

Milei, JoseIcon ; Grana, Daniel RodolfoIcon ; Navari, Carlos; Azzato, Francisco; Guerri Guttenberg, Roberto AndrésIcon ; Ambrosio, Giuseppe
Fecha de publicación: 04/2010
Editorial: SAGE Publications
Revista: Angiology
ISSN: 0003-3197
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Medicina Básica

Resumen

We performed a morphological characterization of intimal thickenings in coronary arteries in the very early stages of life to obtain insights into initial coronary atherogenesis. We examined specimens from 67 infants who had died of noncardiac causes within their first year of life. Serially cut sections were stained with hematoxylin-eosin, Azan, Alcian blue, acetic orceine, and immunotypified for CD68, CD34, and α-smooth muscle (SM) actin. Substantial changes were detected in about 1 of 3 participants. Alterations ranged from focal areas with mild myointimal thickening to diffuse moderate thickening. In those lesions, smooth muscle cells (SMCs) showed loss of polarity, infiltrating the subendothelium, mostly with rupture of the internal elastic lamina and without neoangiogenesis. Morphometrically, in musculoelastic intimal thickenings, neointimal thickness averaged 58.3 ± 17.8 Âμm, affecting 46% of the internal elastic membrane perimeter; lumen stenosis averaged 13.7% ± 5.0%. These lesions can be present very early in life and SMCs seem to play an essential role.
Palabras clave: Coronary Artery , Early Atherosclerosis , Smooth Muscle Cells , Subintimal Thickening
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/67620
DOI: http://dx.doi.org/10.1177/0003319709352487
URL: https://journals.sagepub.com/doi/10.1177/0003319709352487
Colecciones
Articulos(ININCA)
Articulos de INST.DE INVEST.CARDIOLOGICAS (I)
Citación
Milei, Jose; Grana, Daniel Rodolfo; Navari, Carlos; Azzato, Francisco; Guerri Guttenberg, Roberto Andrés; et al.; Coronary intimal thickening in newborn babies and ≤i-Year-old infants; SAGE Publications; Angiology; 61; 4; 4-2010; 350-356
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