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dc.contributor.author
Velez Pardo, Carlos
dc.contributor.author
Jimenez Del Rio, Marlene
dc.contributor.author
Lores Arnaiz, Silvia
dc.contributor.author
Bustamante, Juanita
dc.date.available
2019-01-07T19:28:58Z
dc.date.issued
2010-09
dc.identifier.citation
Velez Pardo, Carlos; Jimenez Del Rio, Marlene; Lores Arnaiz, Silvia; Bustamante, Juanita; Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure; Springer/Plenum Publishers; Neurochemical Research; 35; 9; 9-2010; 1323-1332
dc.identifier.issn
0364-3190
dc.identifier.uri
http://hdl.handle.net/11336/67604
dc.description.abstract
The effects of cannabinoids in mitochondria after acute oxidative stress insult are not fully established. We investigated the ability of CP55,940 and JWH-015 to scavenge reactive oxygen species and their effect on mitochondria permeability transition (MPT) in either A mitochondria-free superoxide anion generation system, intact rat brain mitochondria or in sub-mitochondrial particles (SMP) treated with paraquat (PQ). Oxygen consumption, mitochondrial membrane potential (δ φm) and MPT were determined as parameters of mitochondrial function. It is found that both cannabinoids effectively attenuate mitochondrial damage against PQ-induced oxi-dative stress by scavenging anion superoxide radical (O2-) and hydrogen peroxide (H2O2), maintaining φm and by avoiding Ca2+-induced mitochondrial swelling. Understanding the mechanistic action of cannabinoids on mitochondria might provide new insights into more effective therapeutic approaches for oxidative stress related disorders.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer/Plenum Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cannabinoids
dc.subject
Cp55,940
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Jwh-015 Mitochondria
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Oxidative Stress
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Paraquat
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-07T13:32:52Z
dc.identifier.eissn
1573-6903
dc.journal.volume
35
dc.journal.number
9
dc.journal.pagination
1323-1332
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Velez Pardo, Carlos. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Jimenez Del Rio, Marlene. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Lores Arnaiz, Silvia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Bustamante, Juanita. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.journal.title
Neurochemical Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11064-010-0188-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11064-010-0188-1
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