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dc.contributor.author
Gonzales Castañeda, Cynthia
dc.contributor.author
Rivera, Valery
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Chirinos, Ana Lucía
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Evelson, Pablo Andrés
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dc.contributor.author
Gonzales, Gustavo Francisco
dc.date.available
2019-01-07T19:18:27Z
dc.date.issued
2011-08
dc.identifier.citation
Gonzales Castañeda, Cynthia; Rivera, Valery; Chirinos, Ana Lucía; Evelson, Pablo Andrés; Gonzales, Gustavo Francisco; Photoprotection against the UVB-induced oxidative stress and epidermal damage in mice using leaves of three different varieties of Lepidium meyenii (maca); Wiley Blackwell Publishing, Inc; International Journal Of Dermatology; 50; 8; 8-2011; 928-938
dc.identifier.issn
0011-9059
dc.identifier.uri
http://hdl.handle.net/11336/67596
dc.description.abstract
Background Skin exposure to ultraviolet (UV) B radiation leads to epidermal damage and generation of reactive oxygen species. The photoprotective effect of extracts of three varieties of leaves (red, yellow, and black) from maca (Lepidium meyenii), a plant from the Peruvian highlands, was assessed in mouse skin exposed to UVB radiation. Materials and methods The hydroalcoholic extracts of three varieties of maca leaves were applied topically to the dorsal skin of young-adult male mice prior to exposition to UVB radiation. Results The three varieties had UVA/UVB absorptive properties and presented antioxidant activity, being highest with red maca, followed by black and yellow maca. The three varieties of maca leaves prevented the development of sunburn cells, epidermal hyperplasia, leukocytic infiltration, and other alterations produced by UVB radiation. Mice treated with black maca showed the highest superoxide dismutase levels, and mice treated with black and yellow maca showed higher catalase levels in skin, whereas red maca protected the skin and liver against significant increases in the lipid peroxidation activity observed in the unprotected animals. Conclusion The presence of significant antioxidant activity and the inhibition of lipid peroxidation suggest that the observed protection could be partly attributable to this mechanism. © 2011 The International Society of Dermatology.
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application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lipid Peroxidation
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Uv Radiation
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Maca
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Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Photoprotection against the UVB-induced oxidative stress and epidermal damage in mice using leaves of three different varieties of Lepidium meyenii (maca)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-04T16:29:21Z
dc.journal.volume
50
dc.journal.number
8
dc.journal.pagination
928-938
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Gonzales Castañeda, Cynthia. Universidad Peruana Cayetano Herediam Lima; Perú
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Fil: Rivera, Valery. Universidad Peruana Cayetano Herediam Lima; Perú
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Fil: Chirinos, Ana Lucía. Universidad Peruana Cayetano Herediam Lima; Perú
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Fil: Evelson, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Gonzales, Gustavo Francisco. Universidad Peruana Cayetano Herediam Lima; Perú
dc.journal.title
International Journal Of Dermatology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/j.1365-4632.2010.04793.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-4632.2010.04793.x
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