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dc.contributor.author
Barbagelata, María Sol
dc.contributor.author
Álvarez, Lucía
dc.contributor.author
Gordiola, Mariana Laura
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Tuchscherr, Lorena Paola Nelly
dc.contributor.author
von Eiff, Cristoff
dc.contributor.author
Becker, Karsten
dc.contributor.author
Sordelli, Daniel Oscar
dc.contributor.author
Buzzola, Fernanda Roxana
dc.date.available
2019-01-04T21:59:16Z
dc.date.issued
2011-11
dc.identifier.citation
Barbagelata, María Sol; Álvarez, Lucía; Gordiola, Mariana Laura; Tuchscherr, Lorena Paola Nelly; von Eiff, Cristoff; et al.; Auxotrophic mutant of Staphylococcus aureus interferes with nasal colonization by the wild type; Elsevier Science; Microbes and Infection; 13; 12-13; 11-2011; 1081-1090
dc.identifier.issn
1286-4579
dc.identifier.uri
http://hdl.handle.net/11336/67497
dc.description.abstract
Staphylococcus aureus nasal carriage is a risk factor for infection in humans, particularly in the hospital setting. Bacterial interference was used as an alternative strategy for the prevention of upper respiratory, urogenital and gastrointestinal tract infections. This study was designed to assess if the administration of a live-attenuated aroA mutant of S. aureus is useful as a potential approach to prevent transient staphylococcal nasal carriage by virulent strains. We constructed an aroA mutant of S. aureus Newman strain by homologous recombination. The auxotrophic NK41 mutant was attenuated as determined by the increase of the LD50 after intraperitoneal challenge. In mice, previous nasal colonization with the NK41 mutant significantly reduced the number of CFU of S. aureus (HU-71 and Hde288) clinical isolates and the parental Newman strain. The NK41 mutant was unable to induce a pro-inflammatory response and to damage the invaded human respiratory epithelial cells. Moreover, the cells previously or simultaneously infected with the NK41 mutant were invaded by virulent strains in a significantly lower degree than those of the control group. In conclusion, the attenuated NK41 mutant interfered with the colonization and establishment of pathogenic strains of S. aureus, which produce severe infections. © 2011 Institut Pasteur.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bacterial Interference
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Nasal Carriage
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Staphylococcus Aureus
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Auxotrophic mutant of Staphylococcus aureus interferes with nasal colonization by the wild type
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-04T16:33:26Z
dc.journal.volume
13
dc.journal.number
12-13
dc.journal.pagination
1081-1090
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Barbagelata, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.description.fil
Fil: Álvarez, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.description.fil
Fil: Gordiola, Mariana Laura. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.description.fil
Fil: Tuchscherr, Lorena Paola Nelly. Münster Universitätsklinikum Münster; Alemania
dc.description.fil
Fil: von Eiff, Cristoff. Münster Universitätsklinikum Münster; Alemania
dc.description.fil
Fil: Becker, Karsten. Münster Universitätsklinikum Münster; Alemania
dc.description.fil
Fil: Sordelli, Daniel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.description.fil
Fil: Buzzola, Fernanda Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.journal.title
Microbes and Infection
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.micinf.2011.06.010
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1286457911001705


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