Artículo

Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action

Soberon, Jose RodolfoIcon ; Lizarraga, Emilio FernandoIcon ; Sgariglia, Melina AraceliIcon ; Carrasco Juarez, Marisa B.; Sampietro, Diego AlejandroIcon ; Ben Altabef, AidaIcon ; Catalan, Cesar Atilio NazarenoIcon ; Vattuone, Marta AmeliaIcon
Fecha de publicación: 10/2015
Editorial: Springer
Revista: Anton Leeuw Int. J. G.
ISSN: 0003-6072
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The main secondary metabolite of Senecio nutans is 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone (4HMBA). The antifungal activity of this compound and three derivatives was assessed using Candida albicans. 4HMBA exhibited the highest antifungal activity among the assayed compounds. The Fractional Inhibitory Concentration (FIC = 0.133) indicated a synergistic fungicidal effect of 4HMBA (5 mg L-1) and fluconazole (FLU) (0.5 mg L-1) against the C. albicans reference strain (ATCC 10231). Microscopy showed that 4HMBA inhibits filamentation and reduces cell wall thickness. Our findings s suggest that 4HMBA is an interesting compound to diminish resistance to commercial fungistatic drugs such as fluconazole
Palabras clave: 4-Hydroxy-3-(3-Methyl-2- Butenyl)Acetophenone , Antifungal Activity , Candida Albicans , Filamentation , Fungal Cell Wall , Synergistic Effect
 
Archivos asociados
Thumbnail
 
Tamaño: 1.339Mb
Formato: PDF
.
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/6739
DOI: http://dx.doi.org/ 10.1007/s10482-015-0559-3
DOI: http://dx.doi.org/10.1007/s10482-015-0559-3
URL: http://link.springer.com/article/10.1007%2Fs10482-015-0559-3
Colecciones
Articulos(CCT - NOA SUR)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos(INQUINOA)
Articulos de INST.DE QUIMICA DEL NOROESTE
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Soberon, Jose Rodolfo; Lizarraga, Emilio Fernando; Sgariglia, Melina Araceli; Carrasco Juarez, Marisa B.; Sampietro, Diego Alejandro; et al.; Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action; Springer; Anton Leeuw Int. J. G.; 108; 5; 10-2015; 1047-1057
Compartir
Altmétricas