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dc.contributor.author
Bonofiglio, Laura  
dc.contributor.author
Regueira, Mabel  
dc.contributor.author
Pace, Julio  
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Corso, Alejandra  
dc.contributor.author
García, Ernesto  
dc.contributor.author
Mollerach, Marta Eugenia  
dc.date.available
2019-01-03T19:00:15Z  
dc.date.issued
2011-03  
dc.identifier.citation
Bonofiglio, Laura; Regueira, Mabel; Pace, Julio; Corso, Alejandra; García, Ernesto; et al.; Dissemination of an erythromycin-resistant penicillin-nonsusceptible streptococcus pneumoniae Poland6B-20 clone in Argentina; Mary Ann Liebert; Microbial Drug Resistance: Mechanisms Epidemiology and Disease; 17; 1; 3-2011; 75-81  
dc.identifier.issn
1076-6294  
dc.identifier.uri
http://hdl.handle.net/11336/67317  
dc.description.abstract
Prevalence of serotype 6B penicillin (PEN)-nonsusceptible Streptococcus pneumoniae significantly increased from 15.8% (1993-1997) to 67.3% (1998-2002) (p < 0.001) in Argentina. Serogroup 6 ranks fourth among different capsular types within invasive isolates from Argentinean patients <6 years of age. To evaluate whether the increase in PEN resistance in serotype 6B pneumococci was due to the dissemination of one or more clones, the genetic diversity of 93 S. pneumoniae serotype 6B isolates was analyzed. Five BOX-polymerase chain reaction types were obtained (65.5% isolates) and a group of 15 isolates, representing 41.6% of those having a decreased susceptibility to PEN, were further characterized. The antibiotype of these isolates showed their multiresistance, with 100% of the isolates being resistant to erythromycin, 80% to tetracycline, and 73.3% to trimethoprim-sulfamethoxazole. Of the 15 isolates, 13 belonged to the same pulsed-field gel electrophoresis type and galU cluster and were members of the same clone. The identity of the clone was confirmed in four isolates by multilocus sequence typing. The sequence type found (ST315) corresponds to the Poland6B-20 clone. In summary, BOX-polymerase chain reaction, pulsed-field gel electrophoresis, and galU polymorphism were useful tools to detect the presence of a clone whose identity was confirmed by multilocus sequence typing. The isolates belonging to Poland6B-20 found in this work are described for the first time in Latin America.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Mary Ann Liebert  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
S. Pneumoniae  
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Serotype 6b  
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Poland6b-20  
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Galu  
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Pfge  
dc.subject.classification
Otras Ciencias de la Salud  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Dissemination of an erythromycin-resistant penicillin-nonsusceptible streptococcus pneumoniae Poland6B-20 clone in Argentina  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-01-02T19:55:02Z  
dc.journal.volume
17  
dc.journal.number
1  
dc.journal.pagination
75-81  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Bonofiglio, Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Regueira, Mabel. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: Pace, Julio. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: García, Ernesto. Centro de Investigación Biomédica en Red; España  
dc.description.fil
Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.journal.title
Microbial Drug Resistance: Mechanisms Epidemiology and Disease  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/mdr.2010.0027  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/mdr.2010.0027