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dc.contributor.author
Falzone, Tomas Luis
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dc.contributor.author
Stokin, Gorazd B.
dc.date.available
2019-01-03T17:44:32Z
dc.date.issued
2012-08
dc.identifier.citation
Falzone, Tomas Luis; Stokin, Gorazd B.; Imaging amyloid precursor protein in vivo: An axonal transport assay; Humana Press; Methods in Molecular Biology; 846; 8-2012; 295-303
dc.identifier.issn
1064-3745
dc.identifier.uri
http://hdl.handle.net/11336/67300
dc.description.abstract
Fusion of fluorescent probes to axonally transported proteins represents an established approach that enables live imaging of axonal transport. In this approach, in vivo examination of fluorescent particle dynamics provides information about the length, directionality, and the velocity by which axonally transported proteins travel along axons. Analysis of these parameters provides information about the distribution of axonal proteins and their dynamics in and between different subcellular compartments. Establishing the movement behavior of amyloid precursor protein within axons indicated that live imaging approaches offer the opportunity to significantly enhance our understanding of the biology as well as pathology of axonal transport. This chapter provides a fluorescence-based procedure for measuring axonal transport of APP in cultured newborn mouse hippocampal neurons. © 2012 Springer Science+Business Media, LLC.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Humana Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Amyloid Precursor Protein
dc.subject
Axonal Transport
dc.subject
Fluorescent Probes
dc.subject
In Vivo Fluorescent Imaging
dc.subject
Primary Hippocampal Cell Culture
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Imaging amyloid precursor protein in vivo: An axonal transport assay
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-02T19:39:08Z
dc.journal.volume
846
dc.journal.pagination
295-303
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Falzone, Tomas Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
dc.description.fil
Fil: Stokin, Gorazd B.. University Medical Center; Eslovenia
dc.journal.title
Methods in Molecular Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/978-1-61779-536-7_25
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/protocol/10.1007%2F978-1-61779-536-7_25
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