Combined chemotherapy and ALA-based photodynamic therapy in leukemic murine cells

The effects of combined administration of doxorubicin (DOX) and vincristine (VCR), with 5-aminolevulinic acid photodynamic treatment (ALA-PDT), were analyzed in sensitive murine leukemic cell lines (LBR-) and DOX and VCR chemoresistant LBR-D160 and LBR-V160 cell lines. Low doses of DOX and VCR increased anti-cancer effect of ALA-PDT in LBR-cells. Decrease in cell survival was higher when the combination VCR. +. ALA-PDT was used compared to DOX. +. ALA-PDT. Resistant cell lines LBR-D160 and LBR-V160 were sensitive to ALA-PDT; however, no changes occured when combining therapies. Thus, ALA-PDT can overcome drug resistance and is a good candidate for using treating multidrug resistant (MDR) cells. © 2012 Elsevier Ltd.

Palabras clave: 5-Aminolevulinic Acid , Combined Therapy , Leukemic Cells , Multidrug Resistance , Photodynamic Therapy

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/67294

DOI: https://dx.doi.org/10.1016/j.leukres.2012.04.027

URL: https://www.sciencedirect.com/science/article/pii/S0145212612002020

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Articulos(CIPYP)
Articulos de CENTRO DE INVEST. SOBRE PORFIRINAS Y PORFIRIAS

Citación

Diez, Berenice Andrea; Erntz, G.; Teijo, Maria Julieta; Batlle, Alcira María del C.; Hajos, Silvia Elvira; et al.; Combined chemotherapy and ALA-based photodynamic therapy in leukemic murine cells; Pergamon-Elsevier Science Ltd; Leukemia Research; 36; 9; 9-2012; 1179-1184

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