Artículo
Gene therapy for brain tumors: Basic developments and clinical implementation
Assi, Hikmat; Candolfi, Marianela
; Baker, Gregory; Mineharu, Yohei; Lowenstein, Pedro R.; Castro, Maria Gabriela
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Fecha de publicación:
10/2012
Editorial:
Elsevier Ireland
Revista:
Neuroscience Letters
ISSN:
0304-3940
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Glioblastoma multiforme (GBM) is the most common and deadliest of adult primary brain tumors. Due to its invasive nature and sensitive location, complete resection remains virtually impossible. The resistance of GBM against chemotherapy and radiotherapy necessitate the development of novel therapies. Gene therapy is proposed for the treatment of brain tumors and has demonstrated pre-clinical efficacy in animal models. Here we review the various experimental therapies that have been developed for GBM including both cytotoxic and immune stimulatory approaches. We also review the combined conditional cytotoxic immune stimulatory therapy that our lab has developed which is dependent on the adenovirus mediated expression of the conditional cytotoxic gene, Herpes Simplex Type 1 Thymidine Kinase (TK) and the powerful DC growth factor Fms-like tyrosine kinase 3 ligand (Flt3L). Combined delivery of these vectors elicits tumor cell death and an anti-tumor adaptive immune response that requires TLR2 activation. The implications of our studies indicate that the combined cytotoxic and immunotherapeutic strategies are effective strategies to combat deadly brain tumors and warrant their implementation in human Phase I clinical trials for GBM. © 2012 Elsevier Ireland Ltd.
Palabras clave:
Cytotoxic
,
Flt3l
,
Gene Therapy
,
Glioblastoma
,
Immunotherapy
,
Tk
,
Viral Vectors
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Colecciones
Articulos(BIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos(INBIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Citación
Assi, Hikmat; Candolfi, Marianela; Baker, Gregory; Mineharu, Yohei; Lowenstein, Pedro R.; et al.; Gene therapy for brain tumors: Basic developments and clinical implementation; Elsevier Ireland; Neuroscience Letters; 527; 2; 10-2012; 71-77
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