Artículo
Metazoan Ribosome Inactivating Protein encoding genes acquired by Horizontal Gene Transfer
Lapadula, Walter Jesús
; Marcet, Paula Lorena
; Mascotti, María Laura
; Sánchez Puerta, María Virginia
; Juri Ayub, Maximiliano
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Fecha de publicación:
12/2017
Editorial:
Nature Publishing Group
Revista:
Scientific Reports
ISSN:
2045-2322
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of 28S rRNA. These enzymes are widely distributed among plants and their presence has also been confirmed in several bacterial species. Recently, we reported for the first time in silico evidence of RIP encoding genes in metazoans, in two closely related species of insects: Aedes aegypti and Culex quinquefasciatus. Here, we have experimentally confirmed the presence of these genes in mosquitoes and attempted to unveil their evolutionary history. A detailed study was conducted, including evaluation of taxonomic distribution, phylogenetic inferences and microsynteny analyses, indicating that mosquito RIP genes derived from a single Horizontal Gene Transfer (HGT) event, probably from a cyanobacterial donor species. Moreover, evolutionary analyses show that, after the HGT event, these genes evolved under purifying selection, strongly suggesting they play functional roles in these organisms.
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Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Citación
Lapadula, Walter Jesús; Marcet, Paula Lorena; Mascotti, María Laura; Sánchez Puerta, María Virginia; Juri Ayub, Maximiliano; Metazoan Ribosome Inactivating Protein encoding genes acquired by Horizontal Gene Transfer; Nature Publishing Group; Scientific Reports; 7; 1; 12-2017; 1-10; 1863
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