Artículo
Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy
; Echeverría, Gustavo Alberto
; Piro, Oscar Enrique
; Williams, Patricia Ana María; Ferrer, Evelina Gloria
Fecha de publicación:
05/2017
Editorial:
SciMedCentral
Revista:
Annals of Medicinal Chemistry and Research
ISSN:
2378-9336
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
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Articulos(CEQUINOR)
Articulos de CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Articulos de CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Citación
Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent; SciMedCentral; Annals of Medicinal Chemistry and Research; 3; 1017; 5-2017; 1-11
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