Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Trans-sialidase-based vaccine candidate protects against Trypanosoma cruzi infection, not only inducing an effector immune response but also affecting cells with regulatory/ suppressor phenotype

Prochetto, Estefanía SoledadIcon ; Roldán, Carolina; Bontempi, IvánIcon ; Bertona, Daiana; Peverengo, Luz MaríaIcon ; Vicco, Miguel HernánIcon ; Rodeles Antonelli, Luz MaríaIcon ; Perez, Ana RosaIcon ; Marcipar, Iván SergioIcon ; Cabrera, Gabriel
Fecha de publicación: 05/2017
Editorial: Impact Journals
Revista: Oncotarget
ISSN: 1949-2553
e-ISSN: 1949-2553
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Salud Ocupacional

Resumen

Prophylactic and/or therapeutic vaccines have an important potential to control Trypanosoma cruzi (T. cruzi) infection. The involvement of regulatory/suppressor immune cells after an immunization treatment and T. cruzi infection has never been addressed. Here we show that a new trans-sialidase-based immunogen (TSf) was able to confer protection, correlating not only with beneficial changes in effector immune parameters, but also influencing populations of cells related to immune control. Regarding the effector response, mice immunized with TSf showed a TS-specific antibody response, significant delayed-type hypersensitivity (DTH) reactivity and increased production of IFN-γ by CD8+ splenocytes. After a challenge with T. cruzi, TSf-immunized mice showed 90% survival and low parasitemia as compared with 40% survival and high parasitemia in PBS-immunized mice. In relation to the regulatory/suppressor arm of the immune system, after T. cruzi infection TSf-immunized mice showed an increase in spleen CD4+ Foxp3+ regulatory T cells (Treg) as compared to PBS-inoculated and infected mice. Moreover, although T. cruzi infection elicited a notable increase in myeloid derived suppressor cells (MDSC) in the spleen of PBS-inoculated mice, TSf-immunized mice showed a significantly lower increase of MDSC. Results presented herein highlight the need of studying the immune response as a whole when a vaccine candidate is rationally tested.
Palabras clave: FOXP3 REGULATORY T CELLS , IMMUNE RESPONSE , IMMUNITY , IMMUNOLOGY AND MICROBIOLOGY SECTION , MYELOID-DERIVED SUPPRESSOR CELLS , TRANS-SIALIDASE , TRYPANOSOMA CRUZI , VACCINE
Ver el registro completo
 
Archivos asociados
Thumbnail
 
Tamaño: 144.7Kb
Formato: PDF
.
Descargar
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/66883
DOI: http://dx.doi.org/10.18632/oncotarget.18217
URL: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path
Colecciones
Articulos(IDICER)
Articulos de INSTITUTO DE INMUNOLOGIA CLINICA Y EXPERIMENTAL DE ROSARIO
Citación
Prochetto, Estefanía Soledad; Roldán, Carolina; Bontempi, Iván; Bertona, Daiana; Peverengo, Luz María; et al.; Trans-sialidase-based vaccine candidate protects against Trypanosoma cruzi infection, not only inducing an effector immune response but also affecting cells with regulatory/ suppressor phenotype; Impact Journals; Oncotarget; 8; 35; 5-2017; 58003-58020
Compartir
Altmétricas
 
Estadísticas
Visualizaciones: 120
Descargas: 185

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • Sound Cloud

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

Ministerio
https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES