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dc.contributor.author
Bolzan, Alejandro Daniel  
dc.date.available
2018-12-20T20:09:53Z  
dc.date.issued
2016-12  
dc.identifier.citation
Bolzan, Alejandro Daniel; Effect of chemotherapeutic drugs on telomere length and telomerase activity; Smart Science & Technology; Telomere and Telomerase; 3; 12-2016; 1-11  
dc.identifier.issn
2378-1378  
dc.identifier.uri
http://hdl.handle.net/11336/66877  
dc.description.abstract
Telomeres are specialized nucleoproteic complexes localized at the ends of eukaryotic chromosomes, that maintain their stability and integrity. They protect chromosome ends from fusion and from being recognized as sites of DNA damage, i.e., they distinguish natural DNA ends from DNA ends resulting from breakage events. In mammalian cells, telomeres consist of tandem arrays of the hexanucleotide TTAGGG, oriented 5?? to 3?? towards the end of the chromosomes and associated proteins (the so-called ?gshelterin?h complex), and a large non-coding RNA (named TERRA) which forms an integral component of telomeric heterochromatin. Telomere length is maintained by a dynamic process of telomere shortening and lengthening. Shortening can occur due to nucleolytic degradation and incomplete DNA replication due to the inability of lagging strand synthesis to completely replicate chromosomal ends (i.e., the ?gend replication problem?h), whereas lengthening is primarily accomplished by the action of the enzyme telomerase and occasionally by the so-called Alternative Lengthening of Telomeres (?gALT?h) mechanism, which involves homologous recombination. The maintenance of telomere function is crucial for genomic stability and cell viability. Cells respond to dysfunctional telomeres by undergoing senescence, cell death, or genomic instability. Since telomeres play a fundamental role in maintaining chromosomal/genomic stability and telomerase activity and telomere lengthening play a key role in cancer development and progression, a proper knowledge of the effects of chemotherapeutic drugs on telomere length and telomerase activity in normal as well as tumor cells is of great importance to understand the genomic instability associated with chemotherapy regimens. Therefore, in this review we will summarize our current knowledge concerning the main data available about the effects of chemotherapeutic drugs on telomere length and telomerase activity in mammalian cells.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Smart Science & Technology  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Telomere  
dc.subject
Telomere Length  
dc.subject
Telomerase  
dc.subject
Anticancer Drugs  
dc.subject
Chemotherapeutic Drugs  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Effect of chemotherapeutic drugs on telomere length and telomerase activity  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-09-04T19:54:55Z  
dc.journal.volume
3  
dc.journal.pagination
1-11  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Houston  
dc.description.fil
Fil: Bolzan, Alejandro Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina  
dc.journal.title
Telomere and Telomerase  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.smartscitech.com/index.php/TT/article/view/1488/pdf  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.14800/tt.1488