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dc.contributor.author
Grotz, Estefanía  
dc.contributor.author
Bernabeu, Ezequiel Adrian  
dc.contributor.author
Pappalardo, Monica  
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Chiappetta, Diego Andrés  
dc.contributor.author
Moretton, Marcela Analía  
dc.date.available
2018-12-19T15:19:22Z  
dc.date.issued
2017-10  
dc.identifier.citation
Grotz, Estefanía; Bernabeu, Ezequiel Adrian; Pappalardo, Monica; Chiappetta, Diego Andrés; Moretton, Marcela Analía; Nanoscale Kolliphor® HS 15 micelles to minimize rifampicin self-aggregation in aqueous media; Editions Sante; Journal of Drug Delivery Science and Technology; 41; 10-2017; 1-6  
dc.identifier.issn
1773-2247  
dc.identifier.uri
http://hdl.handle.net/11336/66744  
dc.description.abstract
Tuberculosis is a highly-deadly disease that affects both children and adults. Rifampicin, one of the “first-line” anti tuberculosis drugs, self-aggregates in aqueous solutions where the critical aggregation concentration demonstrated a temperature-dependent behavior. Interestingly, drug self-aggregation could negatively affect the development of liquid aqueous rifampicin pediatric tuberculosis formulations. Therefore, our nanotechnological strategy to minimize this effect was the rifampicin encapsulation within polymeric micelles, employing the commercially available Kolliphor® HS 15, as the micelle-former biomaterial. The results show that Kolliphor® HS 15 is able to prevent rifampicin aqueous self-aggregation and precipitation, when used at certain concentrations. In this context, our work opens the possibility of developing aqueous liquid rifampicin dosage forms for pediatric patients to improve tuberculosis treatment.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Editions Sante  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Kolliphor® Hs 15  
dc.subject
Liquid Pediatric Formulations  
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Physical Stability  
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Polymeric Micelles  
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Rifampicin  
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Self-Aggregation  
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Nano-materiales  
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Nanotecnología  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Nanoscale Kolliphor® HS 15 micelles to minimize rifampicin self-aggregation in aqueous media  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-11-02T17:29:24Z  
dc.journal.volume
41  
dc.journal.pagination
1-6  
dc.journal.pais
Francia  
dc.journal.ciudad
Paris  
dc.description.fil
Fil: Grotz, Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Bernabeu, Ezequiel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Pappalardo, Monica. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Moretton, Marcela Analía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.journal.title
Journal of Drug Delivery Science and Technology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S1773224717302629  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.jddst.2017.06.009