Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic Overview

Iron (Fe) and copper (Cu) overloads in rats showed a dose and time dependent metal accumulationin liver with its associated toxicity. The increased contents of the transition metals markedly enhanced the endogenous free-radical mediated processes of phospholipid peroxidation. Invivo liver chemiluminescence showed an increased production of 1 O2, and a consumption ofreduced glutathione (GSH), the main intracellular antioxidant. Results fit with a Haber-Weiss type molecular mechanism in which Fe or Cu and endogenously produced O2- and H2O2, yield HO radical that initiates free-radical mediated phospholipid peroxidation and protein oxidation.

Palabras clave: Iron , Copper , Toxicity , Liver

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/66739

DOI: https://dx.doi.org/10.17140/LROJ-2-110

URL: https://openventio.org/wp-content/uploads/Iron-and-Copper-Toxicity-in-Rat-Liver-

Colecciones

Articulos(INBIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS

Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY

Citación

Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Acosta, Juan Manuel; Boveris, Alberto Antonio; Repetto, Marisa Gabriela; Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic Overview; Openventio Publishers; Liver Research; 2; 1; 12-2017; 9-13

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