Mostrar el registro sencillo del ítem
dc.contributor.author
D'anna, Maria Cecilia
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Giorgi, Gisela
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Roque, Marta Elena
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2018-12-19T13:57:42Z
dc.date.issued
2011-09
dc.identifier.citation
D'anna, Maria Cecilia; Giorgi, Gisela; Roque, Marta Elena; Immunohistochemical studies on duodenum, spleen and liver in mice: Distribution of ferroportin and prohepcidin in an inflammation model; Sociedad Chilena de Anatomía; International Journal of Morphology; 29; 3; 9-2011; 747-753
dc.identifier.issn
0717-9367
dc.identifier.uri
http://hdl.handle.net/11336/66731
dc.description.abstract
Duodenum, spleen and liver have a crucial role in iron balance on the whole organism and are the major sites of Ferroportin (FPN) expression. Specific regulations between FPN and hepcidin are responsible for changes seen in physiopathological conditions such as inflammation. We studied in vivo effects of turpentine oil-induced acute inflammation on FPN expression, and its relation with prohepcidin and iron mobilization. Immunohistochemical procedures were performed using rabbit anti-mouse FPN and prohepcidin antibodies with goat-labeled polymer-HRP anti-rabbit (DAB) as secondary antibody. Plasma and tissular iron were also studied. Our results showed a notable expression and redistribution of duodenal FPN to basolateral membrane in turpentine-treated mice, compared with supranuclear and the weak basolateral expression observed in healthy mice. Red pulp macrophages of healthy mice showed FPN-hemosiderin co-localization, compared with turpentine-treated mice which showed lack of FPN. In liver of healthy mice, FPN was seen in Kupffer cells, whereas in turpentine-treated mice decreased. In addition, we observed an increment of hepatic prohepcidin with a significant hypoferremia. Our findings demonstrated that acute inflammation induced a differential distribution of FPN, showing a cell type specific response. In macrophages, increased hepatic prohepcidin induced degradation of FPN, resulting in hypoferremia. In enterocytes, the redistribution observed of duodenal FPN reflects a different regulation in this tissue. The observed response of the proteins studied may be part of a cyclical pattern of systemic effects of acute inflammation on mouse tissue.
dc.format
application/pdf
dc.language.iso
spa
dc.publisher
Sociedad Chilena de Anatomía
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Enterocytes
dc.subject
Iron
dc.subject
Macrophages
dc.subject
Mobilization
dc.subject.classification
Inmunología
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Básica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Immunohistochemical studies on duodenum, spleen and liver in mice: Distribution of ferroportin and prohepcidin in an inflammation model
dc.title
Estudios inmunohistoquímicos en duodeno, bazo e hígado de ratón: Distribución de ferroportina y prohepcidina en un modelo de inflamación
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-12-11T16:42:29Z
dc.identifier.eissn
0717-9502
dc.journal.volume
29
dc.journal.number
3
dc.journal.pagination
747-753
dc.journal.pais
Chile
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Temuco
dc.description.fil
Fil: D'anna, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
dc.description.fil
Fil: Giorgi, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
dc.description.fil
Fil: Roque, Marta Elena. Universidad Nacional del Sur; Argentina
dc.journal.title
International Journal of Morphology
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4067/S0717-95022011000300014
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300014&lng=en&nrm=iso&tlng=en
Archivos asociados