Artículo
CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis
Fernández Do Porto, Darío Augusto
; Jurado, Javier Oscar
; Pasquinelli, Virginia
; Alvarez, Ivana Belén
; Aspera, Romina Haydeé; Musella, Rosa María; García, Verónica Edith
Fecha de publicación:
04/2012
Editorial:
Nature Publishing Group
Revista:
Immunology and Cell Biology
ISSN:
0818-9641
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Protective immunity against Mycobacterium tuberculosis is primarily mediated by the interaction of antigen-specific T cells and antigen presenting cells, which often depends on the interplay of cytokines produced by these cells. Costimulatory signals represent a complex network of receptor-ligand interactions that qualitatively and quantitatively influence immune responses. Thus, here we investigated the function of CD137 and CD137L, molecules known to have a central role in immune regulation, during human tuberculosis (TB). We demonstrated that M. tuberculosis antigen stimulation increased both CD137 and CD137L expression on monocytes and NK cells from TB patients and healthy donors, but only up-regulated CD137 on T lymphocytes. Blockage of the CD137 pathway enhanced the levels of interferon (IFN)-γ and tumor necrosis factor (TNF)-α produced by monocytes and NK against M. tuberculosis. In contrast, CD137 blockage significantly decreased the specific degranulation of CD8 + T cells and the percentage of specific IFN-γ and TNF-α producing lymphocytes against the pathogen. Furthermore, inhibition of the CD137 pathway markedly increased T-cell apoptosis. Taken together, our results demonstrate that CD137:CD137L interactions regulate the innate and adaptive immune response of the host against M. tuberculosis. © 2012 Australasian Society for Immunology Inc. All rights reserved.
Palabras clave:
CD137
,
CYTOKINES
,
MONOCYTES
,
NK CELLS
,
T CELLS
,
TUBERCULOSIS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INQUIMAE)
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Fernández Do Porto, Darío Augusto; Jurado, Javier Oscar; Pasquinelli, Virginia; Alvarez, Ivana Belén; Aspera, Romina Haydeé; et al.; CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis; Nature Publishing Group; Immunology and Cell Biology; 90; 4; 4-2012; 449-456
Compartir
Altmétricas