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dc.contributor.author
Scolz, Massimilano
dc.contributor.author
Widlund, Per O.
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Piazza, Silvano
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Bublik, Debora Rosa
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Reber, Simone
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Peche, Leticia Y.
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Ciani, Yari
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Hubner, Nina
dc.contributor.author
Isokane, Mayumi
dc.contributor.author
Monte, Martin
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Ellenberg, Jan
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Hyman, Anthony A.
dc.contributor.author
Schneider, Claudio
dc.contributor.author
Bird, Alexander W.
dc.date.available
2018-12-18T14:59:32Z
dc.date.issued
2012-12
dc.identifier.citation
Scolz, Massimilano; Widlund, Per O.; Piazza, Silvano; Bublik, Debora Rosa; Reber, Simone; et al.; GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration; Public Library of Science; Plos One; 7; 12; 12-2012; 51259-51265
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/66649
dc.description.abstract
The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate multiple pathways promoting cell migration remains unclear. Microtubule plus-end binding proteins (+TIPs) are emerging as important players in many cellular functions, including cell migration. Here we identify a +TIP, GTSE1, that promotes cell migration. GTSE1 accumulates at growing microtubule plus ends through interaction with the EB1+TIP. The EB1-dependent +TIP activity of GTSE1 is required for cell migration, as well as for microtubule-dependent disassembly of focal adhesions. GTSE1 protein levels determine the migratory capacity of both nontransformed and breast cancer cell lines. In breast cancers, increased GTSE1 expression correlates with invasive potential, tumor stage, and time to distant metastasis, suggesting that misregulation of GTSE1 expression could be associated with increased invasive potential. © 2012 Scolz et al.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gtse
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Migracion
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Metastasis
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Microtubulos
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-24T13:51:40Z
dc.journal.volume
7
dc.journal.number
12
dc.journal.pagination
51259-51265
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Scolz, Massimilano. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
dc.description.fil
Fil: Widlund, Per O.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
dc.description.fil
Fil: Piazza, Silvano. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
dc.description.fil
Fil: Bublik, Debora Rosa. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
dc.description.fil
Fil: Reber, Simone. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
dc.description.fil
Fil: Peche, Leticia Y.. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
dc.description.fil
Fil: Ciani, Yari. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
dc.description.fil
Fil: Hubner, Nina. Universitair Medisch Centrum Utrecht; Países Bajos
dc.description.fil
Fil: Isokane, Mayumi. European Molecular Biology Laboratory; Alemania
dc.description.fil
Fil: Monte, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
dc.description.fil
Fil: Ellenberg, Jan. European Molecular Biology Laboratory; Alemania
dc.description.fil
Fil: Hyman, Anthony A.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
dc.description.fil
Fil: Schneider, Claudio. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia. University of Udine; Italia
dc.description.fil
Fil: Bird, Alexander W.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1371/journal.pone.0051259
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051259
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