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dc.contributor.author
Gennari, Laura
dc.contributor.author
Blanco, Alicia
dc.contributor.author
Alberto, Maria Fabiana
dc.contributor.author
Grosso, Silvia
dc.contributor.author
Lazzari, María Ángela
dc.date.available
2018-12-18T13:28:40Z
dc.date.issued
2003-05
dc.identifier.citation
Gennari, Laura; Blanco, Alicia; Alberto, Maria Fabiana; Grosso, Silvia; Lazzari, María Ángela; The concomitant presence of lupus anticoagulant, anticardiolipin and anti-β2-glycoprotein I antibodies could be associated with acquired activated protein c resistance in non-systemic lupus erythematosus patients; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 121; 3; 5-2003; 527-529
dc.identifier.issn
0007-1048
dc.identifier.uri
http://hdl.handle.net/11336/66644
dc.description.abstract
Nojima et al (2002) recently reported the co-existence of lupus anticoagulant (LA) and anti-prothrombin antibodies as a risk factor for the prevalence of acquired activated protein C resistance (APCR) in systemic lupus erythematosus (SLE) patients, which was furthermore associated with venous thromboembolism. The acquired APCR phenotype occurs in the absence of the factor V (FV) Leiden mutationand has been described among patients with antiphospholipid antibodies (APA).There is no clear information about which antibodies are involved in this phenotype. However, an in vitro effect of theanti-b2-glycoprotein I (ab2GPI) antibodies on the response to activated protein C (APC) has been described (Matsuda et al, 1995; Martinuzzo et al, 1996; Galli et al, 1998).We evaluated whether the presence of ACA immunoglobulin (Ig)G and ab2GPI IgG was associated with acquired APCR in 24 LA patients with primary antiphospholipid syndrome.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aca Igg Antibodies
dc.subject
Acquired Apcr
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Antiβ2gpi Igg Antibodies
dc.subject
Lupus Anticoagulant
dc.subject
Non-Sle Patients
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The concomitant presence of lupus anticoagulant, anticardiolipin and anti-β2-glycoprotein I antibodies could be associated with acquired activated protein c resistance in non-systemic lupus erythematosus patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-11-22T14:57:24Z
dc.journal.volume
121
dc.journal.number
3
dc.journal.pagination
527-529
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Gennari, Laura. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
dc.description.fil
Fil: Blanco, Alicia. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
dc.description.fil
Fil: Alberto, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
dc.description.fil
Fil: Grosso, Silvia. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
dc.description.fil
Fil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
dc.journal.title
British Journal of Haematology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1046/j.1365-2141.2003.04304.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2003.04304.x


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