Artículo
Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
Alvarez, Ivana Belén
; Pasquinelli, Virginia
; Jurado, Javier Oscar
; Abbate, Pablo Eduardo; Musella, Rosa María; de la Barrera, Silvia Susana
; García, Verónica Edith
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Fecha de publicación:
08/2010
Editorial:
University of Chicago Press
Revista:
Journal Of Infectious Diseases
ISSN:
0022-1899
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Tuberculous pleurisy allows the study of specific cells at the site of Mycobacterium tuberculosis infection. Among pleural lymphocytes, natural killer (NK) cells are a major source of interferon γ (IFN-γ), and their functions are regulated by activating and inhibitory receptors. Programmed death-1 (PD-1), programmed death ligand 1 (PD-L1), and programmed death ligand 2 (PD-L2) are recognized inhibitory receptors in adaptive immunity, but their role during innate immunity remains poorly understood. We investigated the PD-1:PDL1/ PD-L2 pathway on NK cell effector functions in peripheral blood and pleural fluid from patients with tuberculosis. M. tuberculosis stimulation significantly up-regulated PD-1, PD-L1, and PD-L2 levels on NK cells. Interestingly, a direct correlation between PD-1 and IFN-γ expression on NK cells was observed. Moreover, blockade of the PD-1 pathway markedly augmented lytic degranulation and IFN-γ production of NK cells against M. tuberculosis. Furthermore, PD-1+ NK cells displayed a diminished IFN-γ mean fluorescence intensity, denoting the relevance of PD-1 on IFN-γ regulation. Together, we described a novel inhibitory role played by PD-1:PD-L interactions in innate immunity in tuberculosis. © 2010 by the Infectious Diseases Society of America.
Palabras clave:
Tuberculosis
,
Innate Immunity
,
Costimulation
,
Nk Cells
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Identificadores
Colecciones
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Alvarez, Ivana Belén; Pasquinelli, Virginia; Jurado, Javier Oscar; Abbate, Pablo Eduardo; Musella, Rosa María; et al.; Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis; University of Chicago Press; Journal Of Infectious Diseases; 202; 4; 8-2010; 524-532
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