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dc.contributor.author
Fritzen, Márcio  
dc.contributor.author
Schattner, Mirta Ana  
dc.contributor.author
Quintana Ribeiro, Ana Laura  
dc.contributor.author
Correia Batista, Isabel De Fátima  
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Ventura, Janaina  
dc.contributor.author
Carlos Prezoto, Benedito  
dc.contributor.author
Chudzinski-Tavassi, Ana Marisa  
dc.date.available
2018-12-13T19:46:11Z  
dc.date.issued
2003-12  
dc.identifier.citation
Fritzen, Márcio; Schattner, Mirta Ana; Quintana Ribeiro, Ana Laura; Correia Batista, Isabel De Fátima; Ventura, Janaina; et al.; Lonomia obliqua venom action on fibrinolytic system; Pergamon-Elsevier Science Ltd; Thrombosis Research; 112; 1-2; 12-2003; 105-110  
dc.identifier.issn
0049-3848  
dc.identifier.uri
http://hdl.handle.net/11336/66450  
dc.description.abstract
Accidental skin contact with the Lonomia caterpillar bristles causes a severe hemorrhagic syndrome. While fibrinolytic activation is considered to be the main cause of hemorrhage in Lonomia achelous envenomation, a consumptive coagulopathy was found to be a major component involved in the bleeding complications observed in patients envenomed by contact with Lonomia obliqua. Although we have previously observed that in L. obliqua envenomations, fibrinolysis activation appeared to be secondary to coagulation system activation, there are no reports regarding the ability of L. obliqua venom to activate directly fibrinolytic pathways. We examined the action of L. obliqua crude bristles extract (LOCBE) on several fibrinolytic system components. We demonstrated that LOCBE degraded the A-alpha fibrinogen chain only at high concentrations and after long incubation times. Under these conditions, LOCBE also induced prolongation of the fibrinogen clotting time, but no clot lysis was observed before 24 h. LOCBE did not contain t-PA- or u-PA-like activities. Gel filtration and SDS-PAGE showed that LOCBE did not induce FXIII digestion. In addition, no FXIII activity inhibition was detected by dansylcadaverin method. FXIII levels remained unchanged when FXIII was measured in fibrinogen-depleted LOCBE-treated rat plasma, suggesting that the observed 50% FXIII reduction in rats was related to consumption. In conclusion, our results clearly demonstrated that LOCBE did not display either FXIII inhibition or degradation nor fibrinolytic activity. Furthermore, although proteolytic activity on Aα fibrinogen chain was observed, cross-linked fibrin was not affected by LOCBE. © 2003 Elsevier Ltd. All rights reserved.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Caterpillar  
dc.subject
Envenomation  
dc.subject
Factor Xiii  
dc.subject
Fibrinogen  
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Fibrinolysis  
dc.subject.classification
Medicina Critica y de Emergencia  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Lonomia obliqua venom action on fibrinolytic system  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-11-22T14:53:13Z  
dc.journal.volume
112  
dc.journal.number
1-2  
dc.journal.pagination
105-110  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Elmsford  
dc.description.fil
Fil: Fritzen, Márcio. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil  
dc.description.fil
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Quintana Ribeiro, Ana Laura. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil  
dc.description.fil
Fil: Correia Batista, Isabel De Fátima. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil  
dc.description.fil
Fil: Ventura, Janaina. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil  
dc.description.fil
Fil: Carlos Prezoto, Benedito. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil  
dc.description.fil
Fil: Chudzinski-Tavassi, Ana Marisa. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil  
dc.journal.title
Thrombosis Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0049384803005863  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.thromres.2003.11.005