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dc.contributor.author Calabrese, Graciela Cristina
dc.contributor.author Alberto, Maria Fabiana
dc.contributor.author Tubio, Maria Rosario
dc.contributor.author Marani, Mariela Mirta
dc.contributor.author Fernández De Recondo, Marta E.
dc.contributor.author Lazzari, María Ángela
dc.contributor.author Recondo, Eduardo F.
dc.date.available 2018-12-13T19:02:42Z
dc.date.issued 2004-01
dc.identifier.citation Calabrese, Graciela Cristina; Alberto, Maria Fabiana; Tubio, Maria Rosario; Marani, Mariela Mirta; Fernández De Recondo, Marta E.; et al.; A small fraction of dermatan sulfate with significantly increased anticoagulant activity was selected by interaction with the first complement protein; Pergamon-Elsevier Science Ltd; Thrombosis Research; 113; 3-4; 1-2004; 243-250
dc.identifier.issn 0049-3848
dc.identifier.uri http://hdl.handle.net/11336/66438
dc.description.abstract Dermatan sulfate (DS) is a member of the family of structurally complex, sulfated, linear heteropolysaccharides called glycosaminoglycans (GAGs). It has a similar structure to heparin and heparan sulfate (HS), but with acetylgalactosamine replacing glucosamine, and the uronic acid moiety, mainly iduronic, joined 1→3 to the hexosamine. We are studying the relationships between structure and activities of dermatan sulfate, in particular those associated with the thrombin inhibition mediated by heparin cofactor II (HCII). As we have demonstrated with heparin, a small fraction of dermatan sulfate was isolated by precipitation with the first component of the complement system, under very specific conditions of low ionic strength, and the presence of calcium ions. The sulfate content and the anticoagulant activity of the dermatan sulfate fraction isolated in the precipitate were three and four times greater respectively than the starting material. Our in vivo studies showed that this fraction has threefold higher thrombolytic activity than the DS. All these results suggest that this fraction could be used as a therapeutic agent for thrombi dissolution. © 2004 Elsevier Ltd. All rights reserved.
dc.format application/pdf
dc.language.iso eng
dc.publisher Pergamon-Elsevier Science Ltd
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ANTITHROMBIN
dc.subject AT
dc.subject C1
dc.subject COMPLEMENT SYSTEM
dc.subject CON A
dc.subject CONCANAVALIN A
dc.subject DERMATAN SULFATE
dc.subject DS
dc.subject FREE DERMATAN SULFATE
dc.subject FREE DS
dc.subject GAG
dc.subject GLYCOSAMINOGLYCAN
dc.subject HEPARIN COFACTOR II
dc.subject HS
dc.subject MOLECULAR INTERACTIONS
dc.subject THE FIRST PROTEIN COMPLEX OF THE COMPLEMENT SYSTEM
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title A small fraction of dermatan sulfate with significantly increased anticoagulant activity was selected by interaction with the first complement protein
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-11-22T14:54:28Z
dc.journal.volume 113
dc.journal.number 3-4
dc.journal.pagination 243-250
dc.journal.pais Estados Unidos
dc.journal.ciudad Elmsford
dc.description.fil Fil: Calabrese, Graciela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.description.fil Fil: Alberto, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Tubio, Maria Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.description.fil Fil: Marani, Mariela Mirta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.description.fil Fil: Fernández De Recondo, Marta E.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.description.fil Fil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Recondo, Eduardo F.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
dc.journal.title Thrombosis Research
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.thromres.2004.01.014
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0049384804000143
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)