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dc.contributor.author
Calabrese, Graciela Cristina
dc.contributor.author
Alberto, Maria Fabiana
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Tubio, Maria Rosario
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Marani, Mariela Mirta
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Fernández De Recondo, Marta E.
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Lazzari, María Ángela
dc.contributor.author
Recondo, Eduardo F.
dc.date.available
2018-12-13T19:02:42Z
dc.date.issued
2004-01
dc.identifier.citation
Calabrese, Graciela Cristina; Alberto, Maria Fabiana; Tubio, Maria Rosario; Marani, Mariela Mirta; Fernández De Recondo, Marta E.; et al.; A small fraction of dermatan sulfate with significantly increased anticoagulant activity was selected by interaction with the first complement protein; Pergamon-Elsevier Science Ltd; Thrombosis Research; 113; 3-4; 1-2004; 243-250
dc.identifier.issn
0049-3848
dc.identifier.uri
http://hdl.handle.net/11336/66438
dc.description.abstract
Dermatan sulfate (DS) is a member of the family of structurally complex, sulfated, linear heteropolysaccharides called glycosaminoglycans (GAGs). It has a similar structure to heparin and heparan sulfate (HS), but with acetylgalactosamine replacing glucosamine, and the uronic acid moiety, mainly iduronic, joined 1→3 to the hexosamine. We are studying the relationships between structure and activities of dermatan sulfate, in particular those associated with the thrombin inhibition mediated by heparin cofactor II (HCII). As we have demonstrated with heparin, a small fraction of dermatan sulfate was isolated by precipitation with the first component of the complement system, under very specific conditions of low ionic strength, and the presence of calcium ions. The sulfate content and the anticoagulant activity of the dermatan sulfate fraction isolated in the precipitate were three and four times greater respectively than the starting material. Our in vivo studies showed that this fraction has threefold higher thrombolytic activity than the DS. All these results suggest that this fraction could be used as a therapeutic agent for thrombi dissolution. © 2004 Elsevier Ltd. All rights reserved.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antithrombin
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At
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C1
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Complement System
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Con A
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Concanavalin A
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Dermatan Sulfate
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Ds
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Free Dermatan Sulfate
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Free Ds
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Gag
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Glycosaminoglycan
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Heparin Cofactor Ii
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Hs
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Molecular Interactions
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The First Protein Complex Of the Complement System
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A small fraction of dermatan sulfate with significantly increased anticoagulant activity was selected by interaction with the first complement protein
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-11-22T14:54:28Z
dc.journal.volume
113
dc.journal.number
3-4
dc.journal.pagination
243-250
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Elmsford
dc.description.fil
Fil: Calabrese, Graciela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.description.fil
Fil: Alberto, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
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Fil: Tubio, Maria Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.description.fil
Fil: Marani, Mariela Mirta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.description.fil
Fil: Fernández De Recondo, Marta E.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.description.fil
Fil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Recondo, Eduardo F.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
dc.journal.title
Thrombosis Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.thromres.2004.01.014
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0049384804000143


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