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dc.contributor.author
Karmakar, Paramita
dc.contributor.author
Pujol, Carlos Alberto
dc.contributor.author
Damonte, Elsa Beatriz
dc.contributor.author
Ghosh, Tuhin
dc.contributor.author
Ray, Bimalendu
dc.date.available
2018-12-12T20:30:30Z
dc.date.issued
2010-04
dc.identifier.citation
Karmakar, Paramita; Pujol, Carlos Alberto; Damonte, Elsa Beatriz; Ghosh, Tuhin; Ray, Bimalendu; Polysaccharides from Padina tetrastromatica: Structural features, chemical modification and antiviral activity; Elsevier; Carbohydrate Polymers; 80; 2; 4-2010; 514-521
dc.identifier.issn
0144-8617
dc.identifier.uri
http://hdl.handle.net/11336/66378
dc.description.abstract
Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral therapy. In this study, we have analyzed polysaccharide containing fractions derived from Padina tetrastromatica. A glucan containing α-(1 → 4)-linked glucopyranosyl residues, an alginate with apparent molecular mass of 50 kDa, and a fucoidan were isolated. Further sulfated derivatives of the fucoidan (S1-S3), which contained 0.8-1.2 sulfate groups per monomer unit showed inhibitory activity against herpes simplex virus (HSV) types 1 and 2. Their inhibitory concentration 50% (IC50) values were in the range 0.30-1.05 μg/ml and they lacked cytotoxicity at concentrations up to 1000 μg/ml. The antiviral effect was exerted during virus adsorption to the cell. The degree of sulfation seemed to play an important role because further sulfation of the isolated macromolecules largely influences their in vitro anti-HSV activity. © 2009 Elsevier Ltd. All rights reserved.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Anti-Hsv Activity
dc.subject
Dictyotaceae
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Padina Tetrastromatica
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Polysaccharides
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Sulfation
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Polysaccharides from Padina tetrastromatica: Structural features, chemical modification and antiviral activity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-11-22T16:04:47Z
dc.journal.volume
80
dc.journal.number
2
dc.journal.pagination
514-521
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Karmakar, Paramita. University Of Burdwan; India
dc.description.fil
Fil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
dc.description.fil
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
dc.description.fil
Fil: Ghosh, Tuhin. University Of Burdwan; India
dc.description.fil
Fil: Ray, Bimalendu. University Of Burdwan; India
dc.journal.title
Carbohydrate Polymers
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0144861709007176
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.carbpol.2009.12.014
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