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dc.contributor.author
Gandini, Norberto Ariel
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dc.contributor.author
Fermento, María Eugenia
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dc.contributor.author
Salomón, Débora Gisele
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dc.contributor.author
Obiol, Diego Javier
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dc.contributor.author
Andrés, Nancy Carolina
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dc.contributor.author
Zenklusen, Jean C.
dc.contributor.author
Arevalo, Julian
dc.contributor.author
Blasco, Jorge
dc.contributor.author
Lopez, Alejandro
dc.contributor.author
Facchinetti, Maria Marta
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dc.contributor.author
Curino, Alejandro Carlos
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dc.date.available
2016-07-19T20:33:55Z
dc.date.issued
2013-11
dc.identifier.citation
Gandini, Norberto Ariel; Fermento, María Eugenia; Salomón, Débora Gisele; Obiol, Diego Javier; Andrés, Nancy Carolina; et al.; Heme oxygenase-1 expression in human gliomas and its correlation with poor prognosis in patients with astrocytoma; Springer; Tumor Biology; 35; 3; 11-2013; 2803-2815
dc.identifier.issn
1010-4283
dc.identifier.uri
http://hdl.handle.net/11336/6617
dc.description.abstract
In human glioma tumors, heme oxygenase-1 (HO-1) has been shown to be upregulated both when compared with normal brain tissues and also during oligodendroglioma progression. The cell types that express HO-1 have been shown to be mainly macrophages/microglia and T cells. However, many other reports also demonstrated that cell lines derived from glioma tumors and astrocytes express HO-1 after the occurrence of a wide variety of cell injuries and stressors. In addition, the significance of HO-1 upregulation in glioma had not, so far, been addressed. We therefore aimed at investigating the expression and significance of HO-1 in human glial tumors. For this purpose, we performed a wide screening of HO-1 expression in gliomas by using tissue microarrays containing astrocytomas, oligodendrogliomas, mixed tumors, and normal brain tissues. We subsequently correlated protein expression with patient clinicopathological data. We found differences in HO-1 positivity rates between non-malignant brain (22 %) and gliomas (54 %, p = 0.01). HO-1 was expressed by tumor cells and showed cytoplasmic localization, although 19 % of tumor samples also depicted nuclear staining. Importantly, a significant decrease in the overall survival time of grade II and III astrocytoma patients with HO-1 expression was observed. This result was validated at the mRNA level in a cohort of 105 samples. However, no association of HO-1 nuclear localization with patient survival was detected. In vitro experiments aimed at investigating the role of HO-1 in glioma progression showed that HO-1 modulates glioma cell proliferation, but has no effects on cellular migration. In conclusion, our results corroborate the higher frequency of HO-1 protein expression in gliomas than in normal brain, demonstrate that HO-1 is expressed by glial malignant cells, and show an association of HO-1 expression with patients’ shorter survival time.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Heme Oxygenase-1
dc.subject
Glioma
dc.subject
Astrocytoma
dc.subject
Survival
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Tissue Microarray
dc.subject.classification
Patología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Heme oxygenase-1 expression in human gliomas and its correlation with poor prognosis in patients with astrocytoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-02-22T14:06:46Z
dc.journal.volume
35
dc.journal.number
3
dc.journal.pagination
2803-2815
dc.journal.pais
Suiza
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dc.journal.ciudad
Basel
dc.description.fil
Fil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Obiol, Diego Javier. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Andrés, Nancy Carolina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Zenklusen, Jean C.. National Institute of Health.The Cancer Genome Atlas Program Office; Estados Unidos
dc.description.fil
Fil: Arevalo, Julian. Hospital Municipal General de Agudos Doctor José Penna; Argentina
dc.description.fil
Fil: Blasco, Jorge. Hospital Municipal General de Agudos Doctor José Penna; Argentina
dc.description.fil
Fil: Lopez, Alejandro. Laboratorios IACA, Bahia Blanca; Argentina
dc.description.fil
Fil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
dc.journal.title
Tumor Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1007/s13277-013-1373-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s13277-013-1373-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/24234335
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs13277-013-1373-z
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