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dc.contributor.author
González, María Laura
dc.contributor.author
Causada Calo, Natalia
dc.contributor.author
Santino, Juan Pablo
dc.contributor.author
Dominguez Valentin, Mev
dc.contributor.author
Ferro, Fabiana Alejandra
dc.contributor.author
Sammartino, Inés
dc.contributor.author
Kalfayan, Pablo Germán
dc.contributor.author
Verzura, Maria Alicia
dc.contributor.author
Piñero, Tamara Lejandra
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Cajal, Andrea
dc.contributor.author
Pavicic, Walter Hernan
dc.contributor.author
Vaccaro, Carlos
dc.date.available
2018-12-07T20:02:24Z
dc.date.issued
2018-07
dc.identifier.citation
González, María Laura; Causada Calo, Natalia; Santino, Juan Pablo; Dominguez Valentin, Mev; Ferro, Fabiana Alejandra; et al.; Universal determination of microsatellite instability using BAT26 as a single marker in an Argentine colorectal cancer cohort; Springer; Familial Cancer; 17; 3; 7-2018; 395-402
dc.identifier.issn
1389-9600
dc.identifier.uri
http://hdl.handle.net/11336/66087
dc.description.abstract
Microsatellite instability (MSI) is a hallmark tool for Lynch syndrome (LS) screening and a prognostic marker for sporadic colorectal cancer (CRC). In regions with limited resources and scarce CRC molecular characterization as South America, the implementation of universal MSI screening is under debate for both its purposes. We sought to estimate the frequency of BAT26 in colorectal adenocarcinomas and to determine associated clinical and histological features. Consecutive patients from a CRC registry were included. BAT26 determination was performed in all cases; if instability was found, immunohistochemistry (IHC) and BRAF mutation analyses were done, as appropriate. Differences were assessed by chi-squared or Fisher’s exact test, or by T test or Mann–Whitney. Multiple logistic regression was used to identify factors independently associated with BAT26-unstable tumors. We included 155 patients; mean age was 65.6 (SD 14.4) and 56.1% were male. The frequency of BAT26-unstable tumors was 22% (95% CI 15.7–29.3). Factors independently associated with BAT26-unstable tumors were right colon localization (OR 3.4, 95% CI 1.3–8.7), histological MSI features (OR 5.1, 95% CI 1.9–13.6) and Amsterdam criteria (OR 23.2, 95% CI 1.9–286.7). IHC was altered in 85.3% BAT26-unstable tumors and 70.6% lacked MLH1 expression; 47.8% of these harbored BRAF V600E mutation. We provide evidence to link the frequency of BAT26 to an increased diagnostic yield (up to 1.4-folds) of suspected LS cases in comparison to the revised Bethesda guidelines alone. In regions with limited resources, clinical and histological features associated with BAT26-unstable status could be useful to direct MSI screening in sporadic CRCs and may help guide clinical care and future research.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bat26
dc.subject
Colorectal Cancer
dc.subject
Lynch Syndrome
dc.subject
Microsatellite Instability
dc.subject
Universal Screening
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Universal determination of microsatellite instability using BAT26 as a single marker in an Argentine colorectal cancer cohort
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-22T21:51:13Z
dc.journal.volume
17
dc.journal.number
3
dc.journal.pagination
395-402
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: González, María Laura. Hospital Italiano; Argentina
dc.description.fil
Fil: Causada Calo, Natalia. Hospital Italiano; Argentina. McMaster University; Canadá
dc.description.fil
Fil: Santino, Juan Pablo. Hospital Italiano; Argentina
dc.description.fil
Fil: Dominguez Valentin, Mev. The Norwegian Radium Hospital; Noruega
dc.description.fil
Fil: Ferro, Fabiana Alejandra. Hospital Italiano; Argentina
dc.description.fil
Fil: Sammartino, Inés. Hospital Italiano; Argentina
dc.description.fil
Fil: Kalfayan, Pablo Germán. Hospital Italiano; Argentina
dc.description.fil
Fil: Verzura, Maria Alicia. Hospital Italiano; Argentina
dc.description.fil
Fil: Piñero, Tamara Lejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; Argentina
dc.description.fil
Fil: Cajal, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; Argentina
dc.description.fil
Fil: Pavicic, Walter Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; Argentina
dc.description.fil
Fil: Vaccaro, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; Argentina
dc.journal.title
Familial Cancer
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10689-017-0052-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s10689-017-0052-4
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