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dc.contributor.author
Giai, Constanza
dc.contributor.author
Gonzalez, Cintia Daniela
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Ledo, Camila
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Garofalo, Ailin Natalia
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Di Genaro, Maria Silvia
dc.contributor.author
Sordelli, Daniel Oscar
dc.contributor.author
Gomez, Marisa Ines
dc.date.available
2016-07-19T19:19:24Z
dc.date.issued
2013-11
dc.identifier.citation
Giai, Constanza; Gonzalez, Cintia Daniela; Ledo, Camila; Garofalo, Ailin Natalia; Di Genaro, Maria Silvia; et al.; Shedding of TNFR1 induced by protein A decreases TNF-alfa; availability and inflammation during systemic Staphylococcus aureus infection; American Society for Microbiology; Infection and Immunity; 81; 11; 11-2013; 4200-4207
dc.identifier.issn
0019-9567
dc.identifier.uri
http://hdl.handle.net/11336/6594
dc.description.abstract
Staphylococcus aureus infections are an important concern in public health due to their increasing incidence and high rates of mortality. The S. aureus success as a pathogen is highly related to its enormous capacity to evade the host immune response. The critical role of TNF-alpha in the initial host defense against staphylococcal systemic infection has been demonstrated in experimental models and may partially explain the lack of significant benefits observed in clinical trials attempting to neutralize this cytokine in septic patients. S. aureus protein A plays a key role in regulating inflammation through its ability to bind and signal through the TNF-alpha receptor (TNFR1). In this study, we demonstrate that S. aureus, via protein A mediated signaling, induces early shedding of soluble TNFR1 which precedes the secretion of TNF-alpha in vitro and in vivo. The results obtained using a protein A deficient mutant and tnfr1-/- mice strongly suggest that the increased levels of soluble TNFR1 present during S. aureus experimental infection may neutralize circulating TNF-alpha and impair the host inflammatory response. Early shedding of soluble TNFR1 induced by protein A may constitute a novel mechanism by which S. aureus subverts the host immune response.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Staphylococcus Aureus
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Protein A
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Tnf-Alpha
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Inflammation
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Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Shedding of TNFR1 induced by protein A decreases TNF-alfa; availability and inflammation during systemic Staphylococcus aureus infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-02-22T17:01:36Z
dc.journal.volume
81
dc.journal.number
11
dc.journal.pagination
4200-4207
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Giai, Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Gonzalez, Cintia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Ledo, Camila. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.description.fil
Fil: Garofalo, Ailin Natalia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.description.fil
Fil: Di Genaro, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Sordelli, Daniel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Gomez, Marisa Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Médica; Argentina
dc.journal.title
Infection and Immunity
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://iai.asm.org/content/81/11/4200.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1128/IAI.00593-13
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/IAI.00593-13
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