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dc.contributor.author
Mojica, Maria F.
dc.contributor.author
Papp-Wallace, Krisztina M.
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Taracila, Magdalena A.
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Barnes, Melissa D.
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Rutter, Joseph D.
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Jacobs, Michael R.
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LiPuma, John J.
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Walsh, Thomas J.
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Vila, Alejandro Jose
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Bonomo, Robert A.
dc.date.available
2018-12-05T18:46:16Z
dc.date.issued
2017-09
dc.identifier.citation
Mojica, Maria F.; Papp-Wallace, Krisztina M.; Taracila, Magdalena A.; Barnes, Melissa D.; Rutter, Joseph D.; et al.; Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 61; 10; 9-2017; 1-5
dc.identifier.issn
0066-4804
dc.identifier.uri
http://hdl.handle.net/11336/65900
dc.description.abstract
Stenotrophomonas maltophilia is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for S. maltophilia is urgent. We demonstrate the in vitro efficacy of aztreonam-avibactam (ATM-AVI) against S. maltophilia and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of S. maltophilia, addressing an unmet medical need.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Avibactam
dc.subject
Aztreonam
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S. Maltophilia
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-23T16:36:06Z
dc.journal.volume
61
dc.journal.number
10
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Mojica, Maria F.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados Unidos
dc.description.fil
Fil: Papp-Wallace, Krisztina M.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados Unidos
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Fil: Taracila, Magdalena A.. Case Western Reserve University; Estados Unidos
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Fil: Barnes, Melissa D.. Louis Stokes Veterans Affairs Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos
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Fil: Rutter, Joseph D.. Louis Stokes Veterans Affairs Medical Center; Estados Unidos
dc.description.fil
Fil: Jacobs, Michael R.. University Hospitals Cleveland Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos
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Fil: LiPuma, John J.. University of Michigan; Estados Unidos
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Fil: Walsh, Thomas J.. Weill Cornell Medical Center; Estados Unidos
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Fil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Bonomo, Robert A.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados Unidos. CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology; Estados Unidos
dc.journal.title
Antimicrobial Agents and Chemotherapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/61/10/e00777-17.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1128/AAC.00777-17
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