Artículo
Expression, localization and function of galectin-8, a tandemrepeat lectin, in human tumors
Elola, Maria Teresa
; Ferragut, Fatima Eneida del Valle
; Cardenas Delgado, Victor Manuel
; Nugnes, Lorena Gisela
; Gentilini, Lucas Daniel
; Laderach, Diego Jose
; Troncoso, María Fernanda
; Compagno, Daniel Georges
; Wolfenstein, Carlota Elisa
; Rabinovich, Gabriel Adrián
Fecha de publicación:
03/2014
Editorial:
F. Hernandez
Revista:
Histology and Histopathology
ISSN:
0213-3911
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Galectin-8 (Gal-8) is a ´tandem-repeat´-type galectin, which possesses two carbohydrate recognition domains connected by a linker peptide. Gal-8 complexity is related to the alternative splicing of its mRNA precursor, which is known to generate isoforms. Regarding its carbohydrate-binding specificity, Gal-8 has a unique feature among galectins, since its C-terminal domain has higher affinity for N-glycan-type branched oligosaccharides, while its N-terminal domain shows strong affinity for α2-3-sialylated or 3´-sulfated β-galactosides. We integrate here the available information on Gal-8 expression in different tumor types and attempt to elucidate associations of its expression and localization with tumor progression with the overarching goal of analyzing its potential applications in diagnosis and prognosis. Differential diagnosis is still a prime concern in tumor pathology, and Gal-8 could be of great value in some types of primary or secondary tumors (i.e. papillary thyroid carcinoma, advanced colon carcinoma from patients with distant metastases, or metastases from primary lung carcinoma). The prognostic value of Gal-8 has been described for laryngeal carcinoma as well as advanced colon carcinoma. Further studies are needed to explain the relevance of Gal-8 and its isoforms in tumor pathology and their different intra- or extracellular roles (cytoplasmic, nuclear or extracellular) in tumor biology.
Palabras clave:
Galectin-8
,
Tumor
,
Isoforms
,
Lungs
,
Prostate
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Citación
Elola, Maria Teresa; Ferragut, Fatima Eneida del Valle; Cardenas Delgado, Victor Manuel; Nugnes, Lorena Gisela; Gentilini, Lucas Daniel; et al.; Expression, localization and function of galectin-8, a tandemrepeat lectin, in human tumors; F. Hernandez; Histology and Histopathology; 29; 9; 3-2014; 1093-1105
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