Artículo

The leucine-responsive regulatory protein, Lrp, modulates microcin J25 intrinsic resistance in Escherichia coli by regulating expression of the YojI microcin exporter

Socias, Sergio BenjaminIcon ; Vincent, Paula AndreaIcon ; Salomon, Raul ArmandoIcon
Fecha de publicación: 02/2009
Editorial: American Society for Microbiology
Revista: Journal of Bacteriology
ISSN: 0021-9193
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Many Escherichia coli K-12 strains display an intrinsic resistance to the peptide antibiotic microcin J25. In this study, we present results showing that the leucine-responsive regulatory protein, Lrp, is involved in this phenotype by acting as a positive regulator of YojI, a chromosomally encoded efflux pump which expels microcin out of cells. Exogenous leucine antagonizes the effect of Lrp, leading to a diminished expression of the pump and an increased susceptibility to microcin J25. © 2009, American Society for Microbiology. All Rights Reserved.
Palabras clave: Lrp , Mccj25 , Resistance
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/65832
DOI: https://dx.doi.org/10.1128/JB.01074-08
URL: https://jb.asm.org/content/191/4/1343
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Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Socias, Sergio Benjamin; Vincent, Paula Andrea; Salomon, Raul Armando; The leucine-responsive regulatory protein, Lrp, modulates microcin J25 intrinsic resistance in Escherichia coli by regulating expression of the YojI microcin exporter; American Society for Microbiology; Journal of Bacteriology; 191; 4; 2-2009; 1343-1348
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