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dc.contributor.author
Quintá, Héctor Ramiro

dc.contributor.author
Pasquini, Juana Maria

dc.contributor.author
Rabinovich, Gabriel Adrián

dc.contributor.author
Pasquini, Laura Andrea

dc.date.available
2016-07-18T19:11:07Z
dc.date.issued
2014-02
dc.identifier.citation
Quintá, Héctor Ramiro; Pasquini, Juana Maria; Rabinovich, Gabriel Adrián; Pasquini, Laura Andrea; Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury; Nature Publishing Group; Cell Death and Differentiation; 21; 2-2014; 941-955
dc.identifier.issn
1350-9047
dc.identifier.uri
http://hdl.handle.net/11336/6571
dc.description.abstract
Following spinal cord injury (SCI), semaphorin 3A (Sema3A) prevents axonal regeneration through binding to the neuropilin-1 (NRP-1)/PlexinA4 receptor complex. Here, we show that galectin-1 (Gal-1), an endogenous glycan-binding protein, selectively bound to the NRP-1/PlexinA4 receptor complex in injured neurons through a glycan-dependent mechanism, interrupts the Sema3A pathway and contributes to axonal regeneration and locomotor recovery after SCI. Although both Gal-1 and its monomeric variant contribute to de-activation of microglia, only high concentrations of wild-type Gal-1 (which co-exists in a monomer-dimer equilibrium) bind to the NRP-1/PlexinA4 receptor complex and promote axonal regeneration. Our results show that Gal-1, mainly in its dimeric form, promotes functional recovery of spinal lesions by interfering with inhibitory signals triggered by Sema3A binding to NRP-1/PlexinA4 complex, supporting the use of this lectin for the treatment of SCI patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group

dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Galectin-1
dc.subject
Spinal Cord Injury
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Neuropilin-1
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Semaphorin3a
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Biología Celular, Microbiología

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Ciencias Biológicas

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CIENCIAS NATURALES Y EXACTAS

dc.title
Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-15T19:16:21Z
dc.journal.volume
21
dc.journal.pagination
941-955
dc.journal.pais
Reino Unido

dc.journal.ciudad
Londres
dc.description.fil
Fil: Quintá, Héctor Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina
dc.description.fil
Fil: Pasquini, Juana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Pasquini, Laura Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina
dc.journal.title
Cell Death and Differentiation

dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/cdd/journal/v21/n6/full/cdd201414a.html
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/cdd.2014.14
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1038/cdd.2014.14
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/PMC4013512
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013512/
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