Mostrar el registro sencillo del ítem
dc.contributor.author
Kornblihtt, Alberto Rodolfo

dc.date.available
2018-12-04T14:38:26Z
dc.date.issued
2017-08
dc.identifier.citation
Kornblihtt, Alberto Rodolfo; Epigenetics at the base of alternative splicing changes that promote colorectal cancer; American Society for Clinical Investigation; Journal of Clinical Investigation; 127; 9; 8-2017; 3281-3283
dc.identifier.issn
0021-9738
dc.identifier.uri
http://hdl.handle.net/11336/65705
dc.description.abstract
Chromatin modification influences gene expression by either repressingor activating genes, depending on the specific histone mark. Chromatin structure can also influence alternative splicing of transcripts; however, the mechanisms by which epigenetic marks influence splicing are poorly understood. A report in the current issue of the JCI highlights the biological importance of the coordinated control of alternative pre-mRNA splicingby chromatin structure and transcriptional elongation. Yuan et al. found that mutation of the histone methyl transferase SEDT2 affects alternative splicing fates of several key regulatory genes, including those involved in Wnt signaling. As a consequence, loss of SEDT2 in the intestine aggravated Wnt/β-catenin signaling effects, thereby leading to colorectal cancer.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Clinical Investigation

dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Epigenética
dc.subject
Splicing Alternativo
dc.subject
Cáncer Colorectal
dc.subject.classification
Otras Ciencias Biológicas

dc.subject.classification
Ciencias Biológicas

dc.subject.classification
CIENCIAS NATURALES Y EXACTAS

dc.title
Epigenetics at the base of alternative splicing changes that promote colorectal cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-23T18:10:29Z
dc.journal.volume
127
dc.journal.number
9
dc.journal.pagination
3281-3283
dc.journal.pais
Estados Unidos

dc.journal.ciudad
Ann Arbor
dc.description.fil
Fil: Kornblihtt, Alberto Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title
Journal of Clinical Investigation

dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://www.jci.org/articles/view/96497
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669579/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1172%2FJCI96497
Archivos asociados