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dc.contributor.author
Melian, Elisa
dc.contributor.author
Munguía, A. Beatriz
dc.contributor.author
Faccio Sgiorovello, Ricardo Juan
dc.contributor.author
Palma, Santiago Daniel
dc.contributor.author
Domínguez, Laura
dc.date.available
2018-12-04T13:52:16Z
dc.date.issued
2018-03-16
dc.identifier.citation
Melian, Elisa; Munguía, A. Beatriz; Faccio Sgiorovello, Ricardo Juan; Palma, Santiago Daniel; Domínguez, Laura; The Impact of Solid Dispersion on Formulation, Using Confocal Micro Raman Spectroscopy as Tool to Probe Distribution of Components; Springer; Journal of Pharmaceutical Innovation; 13; 1; 16-3-2018; 58-68
dc.identifier.issn
1939-8042
dc.identifier.uri
http://hdl.handle.net/11336/65693
dc.description.abstract
Purpose: Solid dispersions (SDs) of a poorly water-soluble drug were prepared, and their physicochemical properties were compared to those of control physical mixtures (PMs). Among the multiple techniques used to characterize the solid state of preparations, confocal micro Raman spectroscopy (CMRS) was used as a non-destructive tool to qualitatively probe content uniformity and distribution of drug and carrier. Methods: SDs and PMs of drug (fenbendazole, FBZ) were prepared containing two different carriers (poloxamer P188 or P407) with different drug polymer ratios. The preparations were characterized by powder X-ray diffractometry, Fourier transform infrared spectroscopy, thermal analysis, scanning electron microscopy, and in vitro dissolution assay. In addition, CMRS technique and principal component analysis (PCA) were used in order to statistically define the content uniformity and distribution of the drug within the polymeric matrix. Results: In vitro dissolution results exhibited a marked improvement when the drug was formulated as SD compared to control PM and to pure drug. The solid state of these preparations characterized by X-ray powder diffraction and Fourier transform infrared spectroscopy showed no changes in the crystalline state of the drug and no chemical interactions between the components. Raman studies showed a better content uniformity of the drug within the polymeric matrix when subjected to SD process, correlating with the improved dissolution profile. Conclusion: This study provides evidence of the potential of the confocal Raman imaging technique, providing a fast and powerful method to characterize solid dispersions which could be incorporated towards the use of quality by design (QbD) approaches in pharmaceutical development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CONFOCAL MICRO RAMAN SPECTROSCOPY
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CONTENT UNIFORMITY
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DISSOLUTION RATE
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SOLID DISPERSION
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.subject.classification
Salud Ocupacional
dc.subject.classification
Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The Impact of Solid Dispersion on Formulation, Using Confocal Micro Raman Spectroscopy as Tool to Probe Distribution of Components
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-22T19:35:38Z
dc.journal.volume
13
dc.journal.number
1
dc.journal.pagination
58-68
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Melian, Elisa. Universidad de la República; Uruguay
dc.description.fil
Fil: Munguía, A. Beatriz. Universidad de la República; Uruguay
dc.description.fil
Fil: Faccio Sgiorovello, Ricardo Juan. Universidad de la República; Uruguay
dc.description.fil
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Domínguez, Laura. Universidad de la República; Uruguay
dc.journal.title
Journal of Pharmaceutical Innovation
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s12247-017-9306-9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s12247-017-9306-9
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