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dc.contributor.author
Larrieu, Edmundo Juan
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Mujica, Guillermo
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Gauci, Charles G.
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Vizcaychipi, Katherina
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Seleiman, Marcos
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Herrero, Eduardo
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Labanchi, José Luis
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Araya, Daniel
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Sepúlveda, Luis
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Grizmado, Claudia
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Calabro, Arnoldo
dc.contributor.author
Talmon, Gabriel
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Poggio, Thelma Veronica
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dc.contributor.author
Crowley, Pablo
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Cespedes, Graciela
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Santillán, Graciela
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García Cachau, Mariela
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Lamberti, Roberto
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Gino, Lilia
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Donadeu, Meritxell
dc.contributor.author
Lightowlers, Marshall W.
dc.date.available
2018-12-03T23:57:38Z
dc.date.issued
2015-10-30
dc.identifier.citation
Larrieu, Edmundo Juan; Mujica, Guillermo; Gauci, Charles G.; Vizcaychipi, Katherina; Seleiman, Marcos; et al.; Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact; Public Library of Science; PLoS Neglected Tropical Diseases; 9; 10; 30-10-2015; 1-10
dc.identifier.issn
1935-2735
dc.identifier.uri
http://hdl.handle.net/11336/65675
dc.description.abstract
Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims: Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology: Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results: Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the re-intervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions: Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Echinococcosis Quistica
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Vacuna Eg95
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Ovinos
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Ensayo a Campo
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Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
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info:eu-repo/semantics/article
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info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-27T14:48:18Z
dc.journal.volume
9
dc.journal.number
10
dc.journal.pagination
1-10
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Larrieu, Edmundo Juan. Universidad Nacional de La Pampa; Argentina. Universidad Nacional de Río Negro; Argentina
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Fil: Mujica, Guillermo. Provincia de Río Negro, Ministerio de Salud; Argentina
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Fil: Gauci, Charles G.. University of Melbourne; Australia
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Fil: Vizcaychipi, Katherina. Instituto Nacional de Enfermedades Infecciosas; Argentina. Provincia de Río Negro, Ministerio de Salud; Argentina
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Fil: Seleiman, Marcos. Provincia de Río Negro, Ministerio de Salud; Argentina
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Fil: Herrero, Eduardo. Provincia de Río Negro, Ministerio de Salud; Argentina
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Fil: Labanchi, José Luis. Provincia de Río Negro, Ministerio de Salud; Argentina
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Fil: Araya, Daniel. Provincia de Río Negro, Ministerio de Salud; Argentina
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Fil: Sepúlveda, Luis. Provincia de Río Negro, Ministerio de Salud; Argentina
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Fil: Grizmado, Claudia. Provincia de Río Negro, Ministerio de Salud; Argentina
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Fil: Calabro, Arnoldo. Provincia de Río Negro, Ministerio de Salud; Argentina
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Fil: Talmon, Gabriel. Provincia de Río Negro, Ministerio de Salud; Argentina
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Fil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
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Fil: Crowley, Pablo. Universidad Nacional de Río Negro; Argentina
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Fil: Cespedes, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
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Fil: Santillán, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
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Fil: García Cachau, Mariela. Universidad Nacional de La Pampa; Argentina
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Fil: Lamberti, Roberto. Universidad Nacional de La Pampa; Argentina
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Fil: Gino, Lilia. Universidad Nacional de La Pampa; Argentina
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Fil: Donadeu, Meritxell. University of Melbourne; Australia
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Fil: Lightowlers, Marshall W.. University of Melbourne; Australia
dc.journal.title
PLoS Neglected Tropical Diseases
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pntd.0004134
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004134
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