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dc.contributor.author
Valenzuela Oses, Johanna K.
dc.contributor.author
García, Mónica Cristina
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Feitosa, Valker A.
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Pachioni Vasconcelos, Juliana A.
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Gomes-Filho, Sandro M.
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Lourenço, Felipe R.
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Cerize, Natalia N.P.
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Bassères, Daniela S.
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Rangel-Yagui, Carlota O.
dc.date.available
2018-12-03T19:05:53Z
dc.date.issued
2017-12
dc.identifier.citation
Valenzuela Oses, Johanna K.; García, Mónica Cristina; Feitosa, Valker A.; Pachioni Vasconcelos, Juliana A.; Gomes-Filho, Sandro M.; et al.; Development and characterization of miltefosine-loaded polymeric micelles for cancer treatment; Elsevier Science; Materials Science and Engineering: C; 81; 12-2017; 327-333
dc.identifier.issn
0928-4931
dc.identifier.uri
http://hdl.handle.net/11336/65640
dc.description.abstract
Miltefosine presents antineoplastic activity but high hemolytic potential. Its use in cancer has been limited to treating cutaneous metastasis of breast cancer. To decrease hemolytic potential, we developed a formulation of miltefosine-loaded polymeric micelles (PM) of the copolymer Pluronic-F127. A central composite design was applied and the analysis of variance showed that the optimum level of hydrodynamic diameter and polydispersity index predicted by the model and experimentally confirmed were 29 nm and 0.105, respectively. Thermal analyses confirmed that miltefosine was molecularly dispersed within PM. Pluronic-F127 PM with miltefosine 80 μM presented a significant reduction of hemolytic effect (80%, p < 0.05) in comparison to free drug. In vitro assays against HeLa carcinoma cells demonstrated similar cytotoxicity to free miltefosine and PM. Our results suggest that, by lowering hemolytic potential, miltefosine-loaded Pluronic-F127 PM a promising alternative to broaden this drug use in cancer therapy, as well as of other alkylphosphocholines.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Alkylphosphocholines
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Block-Copolymer
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Cancer Therapy
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Hemolytic Potential
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Miltefosine
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Polymeric Micelles
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Development and characterization of miltefosine-loaded polymeric micelles for cancer treatment
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-22T19:36:26Z
dc.journal.volume
81
dc.journal.pagination
327-333
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Valenzuela Oses, Johanna K.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: García, Mónica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Feitosa, Valker A.. Universidade de Sao Paulo; Brasil. Institute for Technological Research; Brasil
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Fil: Pachioni Vasconcelos, Juliana A.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Gomes-Filho, Sandro M.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Lourenço, Felipe R.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Cerize, Natalia N.P.. Institute for Technological Research; Brasil
dc.description.fil
Fil: Bassères, Daniela S.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Rangel-Yagui, Carlota O.. Universidade de Sao Paulo; Brasil
dc.journal.title
Materials Science and Engineering: C
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0928493117320921
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.msec.2017.07.040
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