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dc.contributor.author
González, Gisela Paula  
dc.contributor.author
Moscoso, Nebel Silvana  
dc.contributor.author
Lago, Fernando Pablo  
dc.date.available
2018-12-03T18:20:04Z  
dc.date.issued
2017-10  
dc.identifier.citation
González, Gisela Paula; Moscoso, Nebel Silvana; Lago, Fernando Pablo; A Review of Clinical and Economic Evaluations Applied to Psychotropic Therapies Used in the Treatment of Schizophrenia in Argentina; Springer International Publishing; PharmacoEconomics - Open; 2; 3; 10-2017; 233-239  
dc.identifier.issn
2509-4262  
dc.identifier.uri
http://hdl.handle.net/11336/65621  
dc.description.abstract
Schizophrenia is considered a serious mental disorder that affects over 21 million people worldwide, and is associated with disability that frequently affects the patient's educational and working performance. In Argentina, two of the most widely used antipsychotics in the treatment of this disorder are haloperidol and risperidone. Both are provided free to patients without health coverage in public health care facilities. In this paper we seek to review the clinical and economic benefits of prescribing psychotropic therapies based on haloperidol (a first-generation antipsychotic that is part of the butyrophenone group of drugs) versus risperidone[an atypical or second-generation antipsychotic (neuroleptic)drug] in adult patients who have been diagnosed with schizophrenia. To achieve this objective, an exhaustive search of relevant articles published between 2006 and April 2017 was conducted. This literature search showed that intermittent treatment usually fails to prevent relapses due to irregular protection, therefore continuous treatment is more effective. Although the injectable formats of both drugs[haloperidol depot and long-acting injectable risperidone(LAIR)] have not proven to have significant differences with regard to clinical effectiveness vis-a`-vis the tablet formats,they showed a lower cost-effectiveness ratio by reducing patients' relapses. Moreover, LAIR exhibits superior cost effectiveness compared with haloperidol depot. Haloperidolis less expensive than risperidone but is less cost effective; in comparison with haloperidol, treatment with risperidone produces (1) an improvement in quality-adjusted life-years,and (2) a significant reduction in negative symptoms. In most cases, antipsychotic treatments are effective in controlling the positive and negative symptoms associated with schizophrenia, allowing patients to live in their communities without any impairments. However, it is extremely important to combine pharmacological treatment with other measures that constitute psychosocial therapy.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer International Publishing  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Evaluación Económica  
dc.subject
Revisión Sistemática  
dc.subject
Esquizofrenia  
dc.subject.classification
Otras Ciencias de la Salud  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
A Review of Clinical and Economic Evaluations Applied to Psychotropic Therapies Used in the Treatment of Schizophrenia in Argentina  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-10-23T21:22:14Z  
dc.identifier.eissn
2509-4254  
dc.journal.volume
2  
dc.journal.number
3  
dc.journal.pagination
233-239  
dc.journal.pais
Suiza  
dc.journal.ciudad
Cham  
dc.description.fil
Fil: González, Gisela Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Económicas y Sociales del Sur. Universidad Nacional del Sur. Departamento de Economía. Instituto de Investigaciones Económicas y Sociales del Sur; Argentina  
dc.description.fil
Fil: Moscoso, Nebel Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Económicas y Sociales del Sur. Universidad Nacional del Sur. Departamento de Economía. Instituto de Investigaciones Económicas y Sociales del Sur; Argentina  
dc.description.fil
Fil: Lago, Fernando Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Económicas y Sociales del Sur. Universidad Nacional del Sur. Departamento de Economía. Instituto de Investigaciones Económicas y Sociales del Sur; Argentina  
dc.journal.title
PharmacoEconomics - Open  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s41669-017-0058-8  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s41669-017-0058-8