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dc.contributor.author
Razuc, Mariela Fernanda
dc.contributor.author
Garrido, Mariano Enrique
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Caro, Yamile S.
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Teglia, Carla Mariela
dc.contributor.author
Goicoechea, Hector Casimiro
dc.contributor.author
Fernández Band, Beatriz Susana
dc.date.available
2016-07-14T21:03:13Z
dc.date.issued
2013-01
dc.identifier.citation
Razuc, Mariela Fernanda; Garrido, Mariano Enrique; Caro, Yamile S.; Teglia, Carla Mariela; Goicoechea, Hector Casimiro; et al.; Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values; Elsevier; Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy; 146; 1-2013; 146-154
dc.identifier.issn
1386-1425
dc.identifier.uri
http://hdl.handle.net/11336/6521
dc.description.abstract
A simple and fast on line spectrophotometric method combined with a hybrid hard–soft modeling multivariate curve resolution (HS-MCR) was proposed for the monitoring of photodegradation reaction of ciprofloxacin under UV radiation. The studied conditions attempt to emulate the effect of sunlight on these antibiotics that could be eventually present in the environment. The continuous flow system made it possible to study the ciprofloxacin degradation at different pH values almost at real time, avoiding errors that could arise from typical batch monitoring of the reaction. On the base of a concentration profiles obtained by previous pure soft-modeling approach, reaction pathways have been proposed for the parent compound and its photoproducts at different pH values. These kinetic models were used as a constraint in the HS-MCR analysis. The kinetic profiles and the corresponding pure response profile (UV–Vis spectra) of ciprofloxacin and its main degradation products were recovered after the application of HS-MCR analysis to the spectra recorded throughout the reaction. The observed behavior showed a good agreement with the photodegradation studies reported in the bibliography. Accordingly, the photodegradation reaction was studied by high performance liquid chromatography coupled with UV–Vis diode array detector (HPLC-DAD). The spectra recorded during the chromatographic analysis present a good correlation with the ones recovered by UV–Vis/HS-MCR method.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Ciprofloxacin
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Photodegradation
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Multivariate Curve Resolution
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Hard-Soft Modeling
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Química Analítica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-04-19T20:54:33Z
dc.journal.volume
146
dc.journal.pagination
146-154
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Garrido, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Caro, Yamile S.. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
dc.description.fil
Fil: Teglia, Carla Mariela. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
dc.description.fil
Fil: Goicoechea, Hector Casimiro. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
dc.description.fil
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
dc.journal.title
Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1386142513000048
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/10.1016/j.saa.2012.12.085
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.saa.2012.12.085
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