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dc.contributor.author
Sun, Wen  
dc.contributor.author
Thiramanas, Raweewan  
dc.contributor.author
Slep, Leonardo Daniel  
dc.contributor.author
Zeng, Xiaolong  
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Mailänder, Volker  
dc.contributor.author
Wu, Si  
dc.date.available
2018-11-26T18:53:39Z  
dc.date.issued
2017-08  
dc.identifier.citation
Sun, Wen; Thiramanas, Raweewan; Slep, Leonardo Daniel; Zeng, Xiaolong; Mailänder, Volker; et al.; Photoactivation of Anticancer Ru Complexes in Deep Tissue: How Deep Can We Go?; Wiley VCH Verlag; Chemistry- A European Journal; 23; 45; 8-2017; 10832-10837  
dc.identifier.issn
0947-6539  
dc.identifier.uri
http://hdl.handle.net/11336/65195  
dc.description.abstract
Activation of anticancer therapeutics such as ruthenium (Ru) complexes is currently a topic of intense investigation. The success of phototherapy relies on photoactivation of therapeutics after the light passes through skin and tissue. In this paper, the photoactivation of anticancer Ru complexes with 671-nm red light through tissue of different thicknesses was studied. Four photoactivatable Ru complexes with different absorption wavelengths were synthesized. Two of them (Ru3 and Ru4) were responsive to wavelengths in the “therapeutic window” (650–900 nm) and could be activated using 671-nm red light after passing through tissue up to 16-mm-thick. The other two (Ru1 and Ru2) could not be activated using red light. Additionally, activated Ru4 caused inhibition of cancer cells. These results suggest that photoactivatable Ru complexes are promising for applications in deep-tissue phototherapy.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley VCH Verlag  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Anticancer  
dc.subject
Metallodrug  
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Photochemistry  
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Phototherapy  
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Ru Complex  
dc.subject.classification
Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Photoactivation of Anticancer Ru Complexes in Deep Tissue: How Deep Can We Go?  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-10-23T18:24:31Z  
dc.journal.volume
23  
dc.journal.number
45  
dc.journal.pagination
10832-10837  
dc.journal.pais
Alemania  
dc.journal.ciudad
Weinheim  
dc.description.fil
Fil: Sun, Wen. Max Planck Institute for Polymer Research; Alemania  
dc.description.fil
Fil: Thiramanas, Raweewan. Max Planck Institute for Polymer Research; Alemania  
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Fil: Slep, Leonardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Química Física; Argentina  
dc.description.fil
Fil: Zeng, Xiaolong. Max Planck Institute for Polymer Research; Alemania  
dc.description.fil
Fil: Mailänder, Volker. Max Planck Institute for Polymer Research; Alemania. Johannes Gutenberg Universitat Mainz; Alemania  
dc.description.fil
Fil: Wu, Si. Max Planck Institute for Polymer Research; Alemania  
dc.journal.title
Chemistry- A European Journal  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1002/chem.201701224  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/chem.201701224  

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