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dc.contributor.author
Rossi, Andrea Silvana
dc.contributor.author
Oliva, Maria Eugenia
dc.contributor.author
Ferreira, María R.
dc.contributor.author
Chicco, Adriana Graciela
dc.contributor.author
Lombardo, Yolanda B.
dc.date.available
2016-07-14T20:57:46Z
dc.date.issued
2013-05
dc.identifier.citation
Rossi, Andrea Silvana; Oliva, Maria Eugenia; Ferreira, María R.; Chicco, Adriana Graciela; Lombardo, Yolanda B.; Dietary chia seed induced changes in hepatic transcription factors and their target lipogenic and oxidative enzyme activities in dyslipidaemic insulin-resistant rats; Cambridge University Press; British Journal of Nutrition; 109; 9; 5-2013; 1617-1627
dc.identifier.issn
0007-1145
dc.identifier.uri
http://hdl.handle.net/11336/6516
dc.description.abstract
The present study analyses the effect of dietary chia seed rich in n-3 a-linolenic acid on the mechanisms underlying dyslipidaemia and liver steatosis developed in rats fed a sucrose-rich diet (SRD) for either 3 weeks or 5 months. The key hepatic enzyme activities such as fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), glucose-6-phosphate dehydrogenase (G-6-PDH), carnitine palmitoyltransferase-1 (CPT-1) and fatty acid oxidase (FAO) involved in lipid metabolism and the protein mass levels of sterol regulatory element-binding protein-1 (SREBP-1) and PPARa were studied. (1) For 3 weeks, Wistar rats were fed either a SRD with 11% of maize oil (MO) as dietary fat or a SRD in which chia seed replaced MO (SRD þ Chia). (2) A second group of rats were fed a SRD for 3 months. Afterwards, half the rats continued with the SRD while for the other half, MO was replaced by chia for 2 months (SRD þ Chia). In a control group, maize starch replaced sucrose. Liver TAG and the aforementioned parameters were analysed in all groups. The replacement of MO by chia in the SRD prevented (3 weeks) or improved/normalised (5 months) increases in dyslipidaemia, liver TAG, FAS, ACC and G-6-PDH activities, and increased FAO and CPT-1 activities. Protein levels of PPARa increased, and the increased mature form of SREBP-1 protein levels in the SRD was normalised by chia in both protocols (1 and 2). The present study provides new data regarding some key mechanisms related to the fate of hepatic fatty acid metabolism that seem to be involved in the effect of dietary chia seed in preventing and normalising/ improving dyslipidaemia and liver steatosis in an insulin-resistant rat model.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cambridge University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Semilla de Chia Dietaria
dc.subject
Dislipidemia
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Ppar Alfa
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Srebp-1
dc.subject.classification
Nutrición, Dietética
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Dietary chia seed induced changes in hepatic transcription factors and their target lipogenic and oxidative enzyme activities in dyslipidaemic insulin-resistant rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-07-06T15:45:24Z
dc.journal.volume
109
dc.journal.number
9
dc.journal.pagination
1617-1627
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Rossi, Andrea Silvana. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina
dc.description.fil
Fil: Oliva, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina
dc.description.fil
Fil: Ferreira, María R.. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina
dc.description.fil
Fil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
dc.description.fil
Fil: Lombardo, Yolanda B.. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina
dc.journal.title
British Journal of Nutrition
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8904742&fileId=S0007114512003558
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1017/S0007114512003558
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1017/S0007114512003558
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