Artículo
Adaptive metabolic rewiring to chronic SFK inhibition
Pinedo Carpio, Edgar; Davidson, David; Martinez Marignac, Veronica Lucrecia
; Panasci, Justin; Aloyz, Raquel
Fecha de publicación:
09/2017
Editorial:
Impact Journals
Revista:
OncoTarget
ISSN:
1949-2553
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Src family kinases (SFK) are key regulators of cellular proliferation, differentiation, survival, motility and angiogenesis. As such, SFK inhibitors are being tested in clinical trials to prevent metastasis as an alternative to current treatment regimens for a variety of cancers including breast cancer. To contribute to the development of molecular tools improving SFK-targeted therapies, we used the SFK inhibitor dasatinib and a well characterized triple negative breast cancer cell line (BT20). Comparison of the response of BT20 cells with acquired resistance to dasatinib and its? parental counterpart suggest that chronic exposure to SFK inhibition results in increased dependency on TGFβ signaling for proliferation, both in the absence or the presence of dasatinib. In addition, we found that acquired (but not de novo) resistance to dasatinib was reduced by non-cytotoxic concentrations compounds hindering on PI3K, mTORC1 signaling, endoplasmic reticulum stress or autophagy.
Palabras clave:
Metabolism
,
Cancer
,
Adquired Resistance
,
Pi3k
,
Skf Inhibitor
,
Tgfb
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Articulos(CICYTTP)
Articulos de CENTRO DE INV.CIENT.Y TRANSFERENCIA TEC A LA PROD
Articulos de CENTRO DE INV.CIENT.Y TRANSFERENCIA TEC A LA PROD
Citación
Pinedo Carpio, Edgar; Davidson, David; Martinez Marignac, Veronica Lucrecia; Panasci, Justin; Aloyz, Raquel; Adaptive metabolic rewiring to chronic SFK inhibition; Impact Journals; OncoTarget; 8; 40; 9-2017; 66758-66768
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