Artículo
Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis
Sabatini, Sebastian Eduardo
; Rocchetta, Iara
; Nahabedian, Daniel Eduardo
; Luquet, Carlos Marcelo
; Eppis, Maria Rosa; Bianchi, Laura; Rios, Maria del Carmen
Fecha de publicación:
11/2011
Editorial:
Elsevier Science Inc
Revista:
Comparative Biochemistry And Physiology. Toxicology & Pharmacology
ISSN:
1532-0456
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The aim of this work was to study the oxidative stress effects and histological alterations caused by dietary copper on the filter-feeding freshwater mussel Diplodon chilensis. Bivalves were fed during 6 weeks with the green algae Scenedesmus vacuolatus previously exposed to copper. Metal concentration in algae cultures and bivalve digestive gland was measured by TXRF. A maximum accumulation of 0.49 μg Cu/mg protein was detected at week 6. Also at this week, the hepatosomatic index (HSI) showed the highest decrease (50%) in response to Cu exposure. SOD and GST activities were significantly increased at weeks 4, 5 and 6, reaching an activity on average 50% higher than in controls for GST. CAT activity and GSH increased significantly at weeks 5 and 6. Despite this response, oxidative damage measured as TBARS and carbonyl groups contents increased significantly at weeks 4, 5 and 6, respectively. Digestive tubule and duct atrophy and cell-type replacement in treated mussels were observed by histological studies. The presence of intracellular rhodanine-positive granules, suggests copper accumulation in intracellular vacuoles of digestive cells. © 2011 Elsevier Inc. All rights reserved.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INIBIOMA)
Articulos de INST. DE INVEST.EN BIODIVERSIDAD Y MEDIOAMBIENTE
Articulos de INST. DE INVEST.EN BIODIVERSIDAD Y MEDIOAMBIENTE
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Sabatini, Sebastian Eduardo; Rocchetta, Iara; Nahabedian, Daniel Eduardo; Luquet, Carlos Marcelo; Eppis, Maria Rosa; et al.; Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis; Elsevier Science Inc; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 154; 4; 11-2011; 391-398
Compartir
Altmétricas