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dc.contributor.author
Ravetti, Soledad
dc.contributor.author
Hergert, Lisandro Yamil
dc.contributor.author
Sparo, Mónica Delfina
dc.contributor.author
Sanchez Bruni, Sergio Fabian
dc.contributor.author
Palma, Santiago Daniel
dc.date.available
2018-11-20T22:13:05Z
dc.date.issued
2016-03
dc.identifier.citation
Ravetti, Soledad; Hergert, Lisandro Yamil; Sparo, Mónica Delfina; Sanchez Bruni, Sergio Fabian; Palma, Santiago Daniel; Challenges in Protein Formulation Focused on Extrusion-Spheronization Process; Anaja Pravinkumar Ingle; International Journal of Pharma Research & Review; 5; 3; 3-2016; 29-38
dc.identifier.issn
2278-6074
dc.identifier.uri
http://hdl.handle.net/11336/64820
dc.description.abstract
Biotechnology revolution had led the overcoming of different types of therapeutic protein because of theirchemical structure can perform specific reactions in the body, increasing efficacy and decreasing side effects.Numerous efforts were made to optimize the physicochemical properties of the proteins used for therapeuticand studied different methods for an effective administration of the protein contained in the medicine,evaluating different routes of administration to achieve the desired therapeutic effects. The delivery systemfor oral pharmaceutical proteins and peptides is still in development stage. There are number of limitationsto oral delivery of proteins such as barriers to peptide bioavailability after oral administration, intestinalmembrane permeability, size, intestinal and hepatic metabolism and solubility. Pellets have shown greatpotential in the delivery of proteins/peptidal drugs. Some strategies of development of oral protein andpeptides has always been challenged, optimizing the safety and efficacy while ensuring the ability tomanufacture the drug while maintaining quality and stability. The pelletization techniques have beenreviewed in numerous papers, is a technique that enables the formation of spherical beads or pellets with amean diameter usually ranging from 0.5-2.0 mm. Pellets are prepared by different techniques, such asextrusion and spheronization. This review discusses challenges in protein formulation that have been used toprepare pelletized dosage forms using the extrusion-spheronization process.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Anaja Pravinkumar Ingle
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Drug Delivery
dc.subject
Multiple-Unit System
dc.subject
Extrussion-Spheronization
dc.subject
Formulation
dc.subject
Pellets
dc.subject.classification
Otras Biotecnologías de la Salud
dc.subject.classification
Biotecnología de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Challenges in Protein Formulation Focused on Extrusion-Spheronization Process
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-23T13:45:02Z
dc.journal.volume
5
dc.journal.number
3
dc.journal.pagination
29-38
dc.journal.pais
India
dc.journal.ciudad
Jalgaon
dc.description.fil
Fil: Ravetti, Soledad. Universidad Nacional de Villa María; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Hergert, Lisandro Yamil. Universidad Nacional de Villa María; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sparo, Mónica Delfina. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina
dc.description.fil
Fil: Sanchez Bruni, Sergio Fabian. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.journal.title
International Journal of Pharma Research & Review
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