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dc.contributor.author
Cutrera, Ana Paula  
dc.contributor.author
Mora, Matias Sebastian  
dc.date.available
2018-11-20T13:59:29Z  
dc.date.issued
2017-06-09  
dc.identifier.citation
Cutrera, Ana Paula; Mora, Matias Sebastian; Selection on MHC in a context of historical demographic change in 2 closely distributed species of tuco-Tucos (ctenomys australis and C. Talarum); Oxford Univ Press Inc; Journal of Heredity; 108; 6; 9-6-2017; 628-639  
dc.identifier.issn
0022-1503  
dc.identifier.uri
http://hdl.handle.net/11336/64712  
dc.description.abstract
Selection necessarily acts within the same current and historical demographic framework as neutral evolutionary processes, and the outcome of the interplay between these forces may vary according to their relative strength. In this study, we compare the variation at a major histocompatibility complex (MHC) locus (DRB exon 2), typically subject to strong diversifying selection, and mitochondrial diversity (D-loop) across populations encompassing the entire distribution of 2 species of South American subterranean rodents: Ctenomys australis and C.Talarum (tuco-Tucos). Although these species are parapatric along most of their distribution, historically they have followed distinct demographic trajectories associated with sea level changes during the Quaternary. We surveyed 8 populations of C. australis and 15 of C.Talarum, from which we analyzed 70 and 212 D-loop haplotypes and 91 and 346 DRB genotypes, respectively. Both species have gone through a recent demographic expansion; however, the signal of this process only encompasses the entire distribution of one of the species: C. australis. While balancing selection on MHC in C.Talarumenhanced DRB diversity at the local level compared to D-loop, although not promoting divergence among populations, in C. australis local diversifying selection may have driven higher population differentiation at DRB than at D-loop. Our findings reinforce the idea that the relative strength of selection acting on MHC genes varies spatially and temporally within and among species, even between species using the same macrohabitat and exposed to similar immune challenges.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Oxford Univ Press Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Balancing Selection  
dc.subject
D-Loop  
dc.subject
Drb Exon 2  
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Subterranean Rodents  
dc.subject.classification
Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Selection on MHC in a context of historical demographic change in 2 closely distributed species of tuco-Tucos (ctenomys australis and C. Talarum)  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-10-23T14:11:41Z  
dc.journal.volume
108  
dc.journal.number
6  
dc.journal.pagination
628-639  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Oxford  
dc.description.fil
Fil: Cutrera, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencia Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina  
dc.description.fil
Fil: Mora, Matias Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencia Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina  
dc.journal.title
Journal of Heredity  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jhered/article/108/6/628/3865731  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/jhered/esx054